Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance.
Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance.
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DOI：
10.1186/1532-429x-14-4
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发表时间：
2012-01-11
期刊：
影响因子：
--
通讯作者：
Spottiswoode BS
中科院分区：
文献类型：
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作者：
Auger DA;Zhong X;Epstein FH;Spottiswoode BS
由于对右心室 (RV) 的研究有限，人们对右心室 (RV) 的机制尚不十分了解。这在一定程度上是由于房车的薄壁、不对称的几何形状和不规则的运动造成的。然而，RV 在心血管功能中起着重要作用。本研究旨在使用三维 (3D) 电影位移编码和受激回波 (DENSE) 心血管磁共振 (CMR) 来描述健康 RV 的复杂机制。全心脏 3D 电影 DENSE 数据是从五名健康志愿者那里获取的。提出了用于 RV 中壁组织跟踪和应变估计的定制后处理算法。提出了一种根据解剖标志将 RV 细分为四个区域的方法，并评估了这些区域中应变的时间演变。 3D 电影 DENSE 组织跟踪方法成功地以高空间分辨率捕获了所有志愿者的 RV 运动和变形。区域拉格朗日峰值表面应变和达到峰值的时间与之前使用心肌标记、DENSE 和应变编码 CMR 的研究相对应。流入区域始终显示出比顶端和流出区域更低的峰值应变，并且达到峰值应变的时间表明 RV 机械激活按以下顺序排列：流入、流出、中部、然后顶端。已开发出无模型技术，可使用 3D 电影 DENSE CMR 以高空间分辨率研究 RV 的心肌力学。健康受试者的区域 RV 应变模式的一致性令人鼓舞，并且该技术可能在评估患病心脏中受损的 RV 力学方面具有临床实用性。
The mechanics of the right ventricle (RV) are not well understood as studies of the RV have been limited. This is, in part, due to the RV's thin wall, asymmetric geometry and irregular motion. However, the RV plays an important role in cardiovascular function. This study aims to describe the complex mechanics of the healthy RV using three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR). Whole heart 3D cine DENSE data were acquired from five healthy volunteers. Tailored post-processing algorithms for RV mid-wall tissue tracking and strain estimation are presented. A method for sub-dividing the RV into four regions according to anatomical land marks is proposed, and the temporal evolution of strain was assessed in these regions. The 3D cine DENSE tissue tracking methods successfully capture the motion and deformation of the RV at a high spatial resolution in all volunteers. The regional Lagrangian peak surface strain and time to peak values correspond with previous studies using myocardial tagging, DENSE and strain encoded CMR. The inflow region consistently displays lower peak strains than the apical and outflow regions, and the time to peak strains suggest RV mechanical activation in the following order: inflow, outflow, mid, then apex. Model-free techniques have been developed to study the myocardial mechanics of the RV at a high spatial resolution using 3D cine DENSE CMR. The consistency of the regional RV strain patterns across healthy subjects is encouraging and the techniques may have clinical utility in assessing disrupted RV mechanics in the diseased heart.