RNA silencing against viruses: molecular arms race between Cucumber mosaic virus and its host
RNA silencing against viruses: molecular arms race between Cucumber mosaic virus and its host
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DOI：
10.1007/s10327-013-0448-4
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发表时间：
2013-04
影响因子：
1.2
通讯作者：
C. Masuta;H. Shimura
中科院分区：
文献类型：
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作者：
C. Masuta;H. Shimura
植物已经发展出RNA沉默作为抗病毒防御机制。为了逃避植物宿主的防御，病毒通过产生RNA沉默抑制蛋白（RSSs）来对抗宿主的抗病毒沉默。虽然已经发现大多数病毒rss的作用模式是通过双链rna结合，但病毒有不同的策略来抵消宿主的抗病毒沉默途径。黄瓜花叶病毒是研究最广泛的病毒RSSs之一，本文综述了黄瓜花叶病毒的2b蛋白，以期对病毒与寄主植物之间的分子军备竞赛提供一些见解。
Plants have developed RNA silencing as an antiviral defense mechanism. To escape from the plant host’s defenses, viruses have countered their host’s antiviral silencing by producing RNA silencing suppressor proteins (RSSs). Although the mode of action of the majority of viral RSSs has been found to be through double-stranded RNA-binding, viruses have different strategies to counteract the host’s antiviral silencing pathways. The 2b protein ofCucumber mosaic virus, which is one of the most extensively studied viral RSSs, is reviewed here to provide insights on the molecular arms race between viruses and their host plants.