ESTRADIOL-INDUCED CONDITIONED TASTE-AVERSION AND PLACE AVERSION IN RATS - SEX-DEPENDENT AND DOSE-DEPENDENT EFFECTS
ESTRADIOL-INDUCED CONDITIONED TASTE-AVERSION AND PLACE AVERSION IN RATS - SEX-DEPENDENT AND DOSE-DEPENDENT EFFECTS
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DOI：
10.1016/0031-9384(91)90427-p
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发表时间：
1991-11-01
影响因子：
2.9
通讯作者：
VANDEPOLL, NE
中科院分区：
文献类型：
--
作者：
DEBEUN, R;JANSEN, E;VANDEPOLL, NE
在雄性和雌性大鼠中研究了不同剂量（0-250 μ g/kg，SC）的雌二醇-17-β（E2）在两瓶选择条件性味觉厌恶和两隔室条件性位置偏爱程序中的作用。 建立了E2的剂量依赖性味觉厌恶和位置厌恶效应，并发现条件味觉厌恶程序比条件位置偏爱程序更敏感地检测E2的厌恶性质。 虽然厌恶属性的E2在两种性别中发现，男性的影响显然比女性更突出。 从这项研究中得出的结论是，E2作为一种无条件的厌恶刺激，在雄性和雌性大鼠能够获得控制不同类型的行为，通过联想学习。
Effects of various doses (0-250-mu-g/kg, SC) of estradiol-17-beta (E2) in a two-bottle choice conditioned taste aversion and a two-compartment conditioned place preference procedure were studied in male and female rats. Dose-dependent taste aversion and place aversion effects of E2 were established, and the conditioned taste aversion procedure was found to be more sensitive in detecting aversive properties of E2 than the conditioned place preference procedure. Although aversive properties of E2 were found in both sexes, the effects were clearly more prominent in males as compared to females. From this study, it was concluded that E2 acts as an unconditioned aversive stimulus in both male and female rats capable of gaining control over different types of behavior by associative learning.