Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI
Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI
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DOI：
10.1002/hbm.20355
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发表时间：
2007-12-01
影响因子：
4.8
通讯作者：
Schachar, Russell
中科院分区：
文献类型：
--
作者：
Chevrier, Andre D.;Noseworthy, Michael D.;Schachar, Russell
本研究采用事件相关功能磁共振成像（fMRI）技术，研究了停止信号任务（SST）中运动反应抑制和绩效监控的神经机制。SST涉及一个执行任务和停止执行响应的偶然要求。我们认为SST的运行和停止阶段都涉及抑制和性能监测的组成部分。本研究的目的是确定是否抑制和性能监控在去和停止阶段的任务激活不同的网络。我们隔离的go阶段活动的基础上的反应抑制，监测，和感觉运动处理，并将这些成功的抑制，以确定基板的反应抑制。使用出现停止信号但执行响应的试验来隔离错误检测活动。这些试验被建模为手特定的围棋试验，随后是错误处理。认知go阶段的过程包括反应抑制和监测和激活右前额和中线网络。反应撤销还激活了右额下回和基底神经节（尾状核）。错误检测调用失败的抑制激活背侧前扣带皮层（dACC）和右中额叶布罗德曼9区。我们的研究结果证实，有不同的方面的抑制和性能监测功能，发挥在不同的阶段在一个给定的试验SST，这些是可分离的使用功能磁共振成像。
We examined the neural substrate of motor response inhibition and performance monitoring in the stop signal task (SST) using event-related functional magnetic resonance imaging (fMRI). The SST involves a go task and the occasional requirement to stop the go response. We posit that both the go and the stop phases of the SST involve components of inhibition and performance monitoring. The goal of this study was to determine whether inhibition and performance monitoring during go and stop phases of the task activated different networks. We isolated go-phase activities underlying response withholding, monitoring, and sensorimotor processing and contrasted these with successful inhibition to identify the substrate of response inhibition. Error detection activity was isolated using trials in which a stop signal appeared but the response was executed. These trials were modeled as a hand-specific go trial followed by error processing. Cognitive go-phase processes included response withholding and monitoring and activated right prefrontal and midline networks. Response withdrawal additionally activated right inferior frontal gyrus and basal ganglia (caudate). Error detection invoked by failed inhibition activated dorsal anterior cingulate cortex (dACC) and right middle frontal Brodmann's area 9. Our results confirm that there are distinct aspects of inhibition and performance monitoring functions which come into play at various phases within a given trial of the SST, and that these are separable using fMRI.