Dietary fat and prostate cancer.
Dietary fat and prostate cancer.
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DOI：
10.1097/01.ju.0000107838.33623.19
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发表时间：
2004-02-01
影响因子：
6.6
通讯作者：
Venkateswaran, Vasundara
中科院分区：
文献类型：
--
作者：
Fleshner, Neil;Bagnell, P. Scott;Venkateswaran, Vasundara
目的：来自组织病理学和移行性研究的数据表明，一个或多个晚期环境启动子参与了临床前列腺癌的发生发展。实验室调查和各种设计的流行病学研究表明，饮食脂肪可能是这些候选肿瘤促进剂之一，但其他研究对这种联系提出了质疑。已经假设的生物学上看似合理的关联包括总能量消耗、雄激素代谢改变、氧化应激、特定脂肪酸消耗和杀虫剂摄入量。我们对饮食脂肪摄入和前列腺癌之间存在关联的现有证据进行了批判性评价，并回顾了生物学上看似合理的关系。材料和方法：对所有33项已发表的研究前列腺癌与饮食脂肪或特定高脂肪食物类型之间关系的病例对照和队列研究进行了批判性评价。八项研究表明有统计学意义的关联，许多研究指出特定类型的高脂肪食物(如牛奶或肉类)与前列腺癌存在显著关联。结果：根据研究膳食脂肪摄入量和前列腺癌的方法学中固有的偏差，我们得出结论，证据是一致的。结论：需要对人体进行确证研究，以更好地确定这种关系。应鼓励饮食干预的前瞻性研究。
Purpose: Data from histopathological and migratory studies suggest that 1 or more late stage environmental promoters are involved in the development of clinical carcinoma of the prostate. Laboratory investigations and variously designed epidemiological studies in man have suggested that dietary fat may be one of these candidate tumor promoters but other studies have questioned this association. The biologically plausible associations that have been hypothesized include total energy consumption, altered androgen metabolism, oxidative stress, specific fatty acid consumption and pesticide intake. We provide a critical appraisal of the existing evidence for an association between dietary fat consumption and prostate cancer, and review the biologically plausible relationships. Materials and Methods: All 33 published case-control and cohort studies that examined the relationship between prostate cancer and dietary fat or specific fatty food types were critically appraised. Eight studies suggested a statistically significant association, and many studies noted significant associations for specific types of fatty foods (eg milk or meat) and prostate cancer. Results: In light of the inherent biases in the methodology of studying dietary fat intake and carcinoma of the prostate, we conclude that the evidence is consistent. Conclusions: Corroborative studies in humans are required to better define this relationship. Prospective studies of dietary intervention should be encouraged.