SMC proteins and chromosome structure
SMC proteins and chromosome structure
复制标题
DOI：
10.1016/s0962-8924(98)01370-1
复制
发表时间：
1998-11-01
影响因子：
19
通讯作者：
Strunnikov, AV
中科院分区：
文献类型：
--
作者：
Strunnikov, AV
染色体的结构主要由染色体相关蛋白决定。SMC（染色体结构维持）家族的成员在原核和真核染色体结构和动力学中起着重要作用。SMC蛋白参与染色体凝聚、姐妹染色质凝聚、性染色体剂量补偿、遗传重组和DNA修复。最近在了解SMC蛋白质的功能方面取得了重大进展-包括鉴定含有SMC的蛋白质复合物的生物化学活性，以及认识到单个SMC蛋白质可能与染色体代谢的看似无关的方面联系起来。
The structure of chromosomes is largely determined by chromosome-associated proteins. Members of the SMC (structural maintenance of chromosomes) family play an important role in both prokaryotic and eukaryotic chromosome structure and dynamics. SMC proteins are involved in chromosome condensation, sister-chromatin cohesion, sex-chromosome dosage compensation, genetic recombination and DNA repair. There have been major advances recently in understanding the function of SMC proteins - including the identification of biochemical activities of SMC-containing protein complexes and the realization that individual SMC proteins might link seemingly unrelated aspects of chromosomal metabolism.