Effect of chloromethyl ketone on the progression of elastase-induced emphysema in hamsters.
Effect of chloromethyl ketone on the progression of elastase-induced emphysema in hamsters.
复制标题
氯甲基酮对仓鼠弹性蛋白酶诱导的肺气肿进展的影响。
DOI：
10.1164/arrd.1982.126.1.174
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Stone,PJ
中科院分区：
文献类型：
--
作者：
Lucey,EC;Stone,PJ
在猪胰腺弹性蛋白酶诱导肺气肿后20天，向仓鼠气管内施用弹性蛋白酶抑制剂（琥珀酰丙氨酰丙氨酰脯氨酰氯甲基酮）不会影响120天时观察到的病变。这项研究表明，肺气肿诱发后 20 至 120 天之间肺体积的逐渐增加并不是由于肺中活性弹性蛋白酶的残留。
Intratracheal administration of an elastase inhibitor (Succinyl alanyl alanyl prolyl valine chloromethyl ketone) into hamsters 20 days after induction of emphysema by porcine pancreatic elastase did not affect the lesion seen at 120 days. This study suggests that the progressive increase in lung volume between 20 and 120 days after emphysema induction was not due to a residue of active elastase in the lungs.