Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies
Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies
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DOI：
10.1016/j.jneuroim.2015.05.005
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发表时间：
2015-07-15
影响因子：
3.3
通讯作者：
Kuwabara, Satoshi
中科院分区：
文献类型：
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作者：
Muto, Mayumi;Mori, Masahiro;Kuwabara, Satoshi
在多发性硬化症（MS）的发病机制中，B细胞/抗体相关的机制近年来受到关注。为了研究自身抗体在多发性硬化症中的作用，我们进行了SEREX，该方法可以环蒂地识别自身抗体。我们在39例多发性硬化症患者中发现了抗细胞骨架蛋白talin1的血清抗体，其水平明显高于43例正常对照(P
In the pathogenesis of multiple sclerosis (MS), B cell/antibody-related mechanisms have recently received attention. To investigate the role of autoantibody in MS, we performed SEREX which can identify autoantibody cyclopedically. We identified serum antibodies against cytoskeletal protein talin1, and the levels of whom were remarkably higher in 39 MS than 43 normal controls (P