The relationship between inflammatory dietary pattern and incidence of periodontitis.
The relationship between inflammatory dietary pattern and incidence of periodontitis.
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DOI：
10.1017/s0007114520005231
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发表时间：
2021-12-14
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影响因子：
--
通讯作者：
Joshipura KJ
中科院分区：
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作者：
Alhassani AA;Hu FB;Rosner BA;Tabung FK;Willett WC;Joshipura KJ
饮食的长期炎症影响可能通过改变全身炎症而潜在地增加牙周病的风险。本研究的目的是前瞻性地调查基于食物的降秩回归（RRR）推导的经验性饮食炎症模式（EDIP）与牙周炎发病率之间的关系。研究人群由来自卫生专业人员随访研究的34，940名男性组成，他们在基线（1986年）没有牙周疾病和重大疾病。参与者每2年通过邮寄问卷提供病史和牙科史，每4年通过验证的半定量食物频率问卷提供饮食数据。我们使用考克斯比例风险模型来研究EDIP评分和24年随访期间有效的自我报告牙周病发病率之间的关系。EDIP和牙周炎风险之间没有观察到总体关联; EDIP最高五分位数（最促炎饮食）与最低五分位数相比的风险比为0.99（95%置信区间：0.89 - 1.10，趋势p值= 0.97）。二次分析显示，在肥胖非吸烟者（即基线时从不吸烟和既往吸烟者）中，EDIP最高五分位数与最低五分位数相比，牙周炎的风险比为1.39（95%置信区间：0.98 - 1.96，趋势p值= 0.03）。总之，在研究人群中，EDIP和自我报告的牙周炎发病率之间没有总体相关性。从评估的亚组中，EDIP仅在肥胖的非吸烟者中与牙周炎风险增加显著相关。因此，必须谨慎解释这种关联。
The long-term inflammatory impact of diet could potentially elevate the risk of periodontal disease through modification of systemic inflammation. The aim of the present study was to prospectively investigate the associations between a food based, reduced rank regression (RRR) derived, empirical dietary inflammatory pattern (EDIP) and incidence of periodontitis. The study population was composed of 34,940 men from the Health Professionals Follow-Up Study, who were free of periodontal disease and major illnesses at baseline (1986). Participants provided medical and dental history through mailed questionnaires every 2 years, and dietary data through validated semi-quantitative food frequency questionnaires every 4 years. We used Cox proportional hazard models to examine the associations between EDIP scores and validated self-reported incidence of periodontal disease over a 24-year follow-up period. No overall association between EDIP and the risk of periodontitis was observed; the hazard ratio comparing the highest EDIP quintile (most proinflammatory diet) to the lowest quintile was 0.99 (95% confidence interval: 0.89 −1.10, p-value for trend = 0.97). A secondary analysis showed that among obese non-smokers (i.e. never and former smokers at baseline), the hazard ratio for periodontitis comparing the highest EDIP quintile to the lowest was 1.39 (95% confidence interval: 0.98 −1.96, p-value for trend = 0.03). In conclusion, no overall association was detected between EDIP and incidence of self-reported periodontitis in the study population. From the subgroups evaluated EDIP was significantly associated with increased risk of periodontitis only among nonsmokers who were obese. Hence, this association must be interpreted with caution.