Lung function in prematurely delivered rabbits treated with a synthetic surfactant.
Lung function in prematurely delivered rabbits treated with a synthetic surfactant.
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用合成表面活性剂处理的早产兔子的肺功能。
DOI：
10.1164/ajrccm/136.3.651
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Schlueter,MA
中科院分区：
文献类型：
--
作者：
Tooley,WH;Clements,JA;Muramatsu,K;Brown,CL;Schlueter,MA
我们用名为Exosurf的合成表面活性剂治疗早产的幼兔。按重量计，Exosurf为61.8%棕榈酰磷脂酰胆碱、6.8%羟基癸醇、4.6%泰洛沙泊和26.7%氯化钠。这种简单的混合物，悬浮在15毫克/毫升水中，具有肺表面活性物质替代物的适当的体内特性。根据通气30分钟后进行的静态压力容积关系，用ExosurfaccaptecI治疗的肺显著低于对照组。
Wetreated prematurely delivered rabbit pups with the synthetic surfactant that has been named Exosurf. Byweight, Exosurf Is 61.8% dlpalmltoylphosphatldylchollne, 6.8% huBdecanol, 4.6% tyloxapol, and 26.7% NaC!. This simple mixture, suspended at 15 mg IIpld'ml-'water, has appropriateIn rltro characteristics for a lung surfactant substitute. As datermlned by static preasure volume relationships performed after 30 min ventilation, lungs treated with ExosurfaccaptecI signif-