PSP94 expression after androgen deprivation therapy: A comparative study with prostate specific antigen in benign prostate and prostate cancer
PSP94 expression after androgen deprivation therapy: A comparative study with prostate specific antigen in benign prostate and prostate cancer
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DOI：
10.1016/s0022-5347(05)67113-3
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发表时间：
2000-11-01
影响因子：
6.6
通讯作者：
Moussa, M
中科院分区：
文献类型：
--
作者：
Imasato, Y;Xuan, JW;Moussa, M
目的：为了探讨PSP94（前列腺分泌蛋白94个氨基酸）作为雄激素独立标志物的临床应用，我们对雄激素剥夺和非雄激素剥夺的前列腺样本（包括良性组织和癌组织）进行了比较研究。材料与方法：163例根治性前列腺切除术患者中，术前雄激素剥夺75例，术前未接受激素治疗者行手术治疗。考虑到激素治疗后的病理分级，对根治性前列腺切除术标本的连续切片进行PSP94和前列腺特异性抗原（PSA）的免疫组化染色，并通过染色的强度和程度来评估等效肿瘤灶。结果：未经预处理组前列腺良性组织PSP94、PSA染色均呈阳性，各切片相同。而雄激素剥夺组PSP94的表达强度（p = 0.0005）和程度（p = 0.034）均显著高于PSA。在未经治疗的癌症病例中，PSP94的强度和范围与Gleason分级呈强烈的负相关(p
Purpose: To examine the clinical use of PSP94 (prostate secretory protein of 94 amino acids) as an androgen independent marker, we conducted a comparative study of prostate samples including benign tissue and cancers which did and did not have androgen deprivation.Materials and Methods: Among 163 radical prostatectomy cases 75 had androgen deprivation before operation, while surgery was performed in the remainder without prior hormone treatment. Considering the pathological up grading following hormone therapy, contiguous sections from radical prostatectomy samples were stained for PSP94 and prostate specific antigen (PSA) by immunohistochemistry, and equivalent tumor foci were evaluated by assessing the intensity and extent of the staining.Results: In untreated benign prostate tissue PSP94 and PSA staining was positive and identical in all sections in the no pretreatment group. However, PSP94 expression in the androgen deprivation group was significantly higher than PSA in intensity (p = 0.0005) and extent (p = 0.034). In untreated cancer cases PSP94 intensity and extent demonstrated strong inverse association with Gleason grade (p