Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA
Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA
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DOI：
10.1021/ja057954f
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发表时间：
2006-02-22
影响因子：
15
通讯作者：
Cohen, SM
中科院分区：
文献类型：
--
作者：
Puerta, DT;Botta, M;Cohen, SM
已经制备了两种三足、六齿吡喃酮基螯合剂。这些配体与钆(III) 形成稳定、可溶的络合物。该配合物在 pH 7.4 下表现出与 [Gd(DTPA)]2-相当的水稳定性。通过弛豫测量的评估表明，这些复合物具有两个内层水分子和非常快的水交换速率。这些复合物的溶液行为表明它们作为高弛豫率的下一代磁共振成像造影剂可能很有吸引力。
Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2-at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.