Amino acid and peptide synthesis and functionalization by the reaction of thioacids with 2,4-dinitrobenzenesulfonamides
Amino acid and peptide synthesis and functionalization by the reaction of thioacids with 2,4-dinitrobenzenesulfonamides
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DOI：
10.1021/ol701583t
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发表时间：
2007-10-25
期刊：
影响因子：
5.2
通讯作者：
Guo, Songpo
中科院分区：
文献类型：
--
作者：
Crich, David;Sana, Kasinath;Guo, Songpo
[图表]容易制备的氨基硫代酸在碳酸铯的存在下在室温下在DMF中与2，4-二硝基苯磺酰胺反应得到酰胺。当磺酰胺衍生自氨基酸时，该方法导致肽键形成，而使用碳水化合物衍生的磺酰胺得到新糖缀合物。
[GRAPHICS]Readily prepared amino thioacids react at room temperature in DMF in the presence of cesium carbonate with 2,4-dinitrobenzenesulfonamides to give amides. When the sulfonamide is derived from an amino acid the method results in peptide bond formation, whereas the use of carbohydrate derived sulfonamides gives neoglycoconjugates.