Effects of prenatal stress on corticosteroid receptors and monoamine concentrations in limbic areas of suckling piglets (Sus scrofa) at different ages
Effects of prenatal stress on corticosteroid receptors and monoamine concentrations in limbic areas of suckling piglets (Sus scrofa) at different ages
复制标题
DOI：
10.1046/j.1439-0442.2003.00513.x
复制
发表时间：
2003-04-01
期刊：
影响因子：
--
通讯作者：
Manteuffel, G
中科院分区：
文献类型：
--
作者：
Kanitz, E;Otten, W;Manteuffel, G
本研究旨在通过测定家猪不同边缘脑区皮质类固醇受体结合量和单胺浓度的变化，揭示产前应激对家猪中枢应激调节的影响。妊娠母猪在妊娠的最后5周每天接受5min的束缚应激。在出生后第一天，母亲应激导致海马糖皮质激素受体的数量显著增加，但后代下丘脑的糖皮质激素受体数量减少。未发现海马盐皮质激素受体的改变。胎儿期应激对脑单胺类物质的浓度也没有显著影响。出生后第3天，产前应激仔猪的基础血浆皮质醇水平降低，皮质类固醇结合球蛋白浓度升高，表明出生后游离皮质醇浓度降低。哺乳期间的发病率和死亡率在产前应激产仔中显著增加，表现为每窝仔猪患病和死亡的频率更高。综上所述，结果表明，在猪妊娠晚期，束缚应激影响胎儿神经内分泌反馈系统的个体发育，从而影响下丘脑-垂体-肾上腺功能的调节和后代的活力。
The present study was conducted in order to reveal the effects of prenatal stress on the central stress regulation in domestic pigs by measuring changes in corticosteroid receptor binding and monoamine concentrations in different limbic brain regions. Pregnant sows were subjected to a restraint stress for 5 min daily during the last 5 weeks of gestation. Maternal stress resulted in a significantly higher number of glucocorticoid receptors in the hippocampus, but decreased glucocorticoid receptors in the hypothalamus of the offspring at the first postnatal day. No alterations of hippocampal mineralocorticoid receptors were found. There was also no significant effect of prenatal stress on the brain monoamine concentrations. Prenatally stressed piglets showed lower basal plasma cortisol and increased corticosteroid binding globulin concentrations at the third postnatal day indicating decreased free cortisol concentrations after birth. Morbidity and mortality during the suckling period were significantly increased in prenatally stressed litters, as shown by a higher frequency of diseased and died piglets per litter. In conclusion, the results indicate that in pigs restraint stress during late gestation affects the ontogeny of the foetal neuroendocrine feedback system with consequences for the regulation of the hypothalamo-pituitary-adrenal function and the vitality of the offspring.