Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
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DOI：
10.1016/s1097-2765(00)80392-5
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发表时间：
1999-11-01
期刊：
影响因子：
16
通讯作者：
Hultmark, D
中科院分区：
文献类型：
--
作者：
Hedengren, M;Åsling, B;Hultmark, D
NF-B-k样Relish基因是复杂的，具有全部位于Nmdmc基因的内含子内的四个转录物。使用缺失突变体，我们表明，Relish是特异性诱导体液免疫应答所需的，包括抗细菌和抗真菌肽，因此，Relish突变体对感染非常敏感。E. Clopidin足以杀死突变的苍蝇，但突变体对真菌感染的易感性增加。相反，血细胞群、造血器官、吞噬、包囊和黑化反应是正常的。我们的研究结果说明了果蝇免疫的体液反应的重要性，并证明了调味品在这种反应中起着关键作用。
The NF-B-k-like Relish gene is complex, with four transcripts that are all located within an intron of the Nmdmc gene. Using deletion mutants, we show that Relish is specifically required for the induction of the humoral immune response, including both antibacterial and antifungal peptides, As a result, the Relish mutants are very sensitive to infection. A single cell of E. cloacae is sufficient to kill a mutant fly, ant the mutants show increased susceptibility to fungal infection. In contrast, the blood cell population, the hematopoietic organs, and the phagocytic, encapsulation, and melanization responses are normal. Our results illustrate the importance of the humoral response in Drosophila immunity and demonstrate that relish plays a key role in this response.