Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: A pathological study of 1074 consecutive autopsy cases
Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: A pathological study of 1074 consecutive autopsy cases
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DOI：
10.1016/j.atherosclerosis.2005.07.023
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发表时间：
2006-06-01
期刊：
影响因子：
5.3
通讯作者：
Tanaka, N
中科院分区：
文献类型：
--
作者：
Sawabe, M;Arai, T;Tanaka, N
简介：流行病学调查显示，老年人心血管疾病死亡率中男性占优势的情况有所减少或逆转，但老年人动脉粥样硬化的实际情况在很大程度上是未知的。本文的目的是揭示动脉粥样硬化是否继续进展，或存在与性别有关的差异在veryold.Methods：对象是1074例连续尸检的住院死亡病例。男女比例为1.1：1，平均年龄为80岁。对颅内动脉、颈动脉、主动脉、冠状动脉、股动脉等10条动脉的动脉粥样硬化程度进行宏观评价。动脉粥样硬化程度随年龄增长而增加，即使在80岁以后也是如此。结论：高龄女性心血管病死亡率的增加可能与动脉粥样硬化的持续进展和性别差异的消失有关。他们还表明，预防动脉粥样硬化进展在生命的第七和第八十年仍然很重要。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Introduction: Epidemiological surveys show decrease or reversal of male predominance in cardiovascular mortality in the very old, but the actual condition of atherosclerosis in the very old is largely unknown. The objective of this paper is to reveal whether the atherosclerosis continues to progress, or the gender-related difference exists in the very old.Methods: The subjects were 1074 consecutive autopsy cases of in-hospital death. The male:female ratio was 1.1:1 and the average age was 80 years. Macroscopic evaluation was per-formed on the degree of atherosclerosis in 10 arteries including the intracranial arteries, carotid artery, aorta, coronary artery, and femoral artery.Results: The severity of atherosclerosis differed greatly among arteries. The age-related increase of the atherosclerotic degree was evident, even after 80 years of age. The atherosclerosis was more severe in males than in females in their 60s, but this male predominance decreased with ageing and finally disappeared in their 90s.Conclusion: The sustained progression of atherosclerosis and loss of the gender-related difference probably account for the increase of cardiovascular mortality in very old females. They also suggest that the prevention of the atherosclerotic progression is still important in the seventh and eighth decade of life. (c) 2005 Elsevier Ireland Ltd. All rights reserved.