Role of plasma insulin concentration in regulating glucose and lipid metabolism in lean and obese Zucker rats
Role of plasma insulin concentration in regulating glucose and lipid metabolism in lean and obese Zucker rats
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DOI：
10.1038/sj.ijo.0800375
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发表时间：
1997-02-01
影响因子：
4.9
通讯作者：
Shikama, H
中科院分区：
文献类型：
--
作者：
Noshiro, O;Hirayama, R;Shikama, H
目的：为了确定血浆胰岛素浓度在调节胰岛素抵抗的肥胖Zucker大鼠中的葡萄糖和脂质代谢中的作用，并比较肥胖大鼠与瘦对照大鼠在胰岛素敏感性变化方面的差异。设计：瘦和肥胖大鼠的动物研究，使用或不使用胰岛素增敏剂YM 268。动物：9周龄雄性瘦（Fa/-）和肥胖（fa/fa）Zucker大鼠。血糖、胰岛素、甘油三酯（TG）、非酯化脂肪酸（NEFA）、胆固醇在基线和14天后，YM 268剂量显示每个参数降低30%（艾德（30））。YM 268对血糖没有影响，但在艾德（30）为3.0和2.9 mg/kg的瘦和肥胖大鼠中降低胰岛素。YM 268还降低瘦和肥胖大鼠中的TG和NEFA [艾德（30）（mg/kg）：瘦; 4.1（TG），5.0（NEFA），肥胖; 2.1，3.0]。结论：瘦和肥胖Zucker大鼠的血浆TG和NEFA水平与胰岛素相关，而胆固醇水平与胰岛素无关，肥胖大鼠对TG和NEFA代谢的胰岛素敏感性可能与瘦大鼠无差异。
OBJECTIVE: To determine the role of plasma insulin concentration in regulating glucose and lipid metabolism in insulin-resistant obese Zucker rats and to compare obese rats with lean controls with respect to changes in insulin sensitivity.DESIGN: Animal study of lean and obese rats with or without insulin sensitizer, YM268.ANIMALS: Nine week old male lean (Fa/-) and obese (fa/fa) Zucker rats.MEASUREMENTS: Plasma glucose, insulin, triglyceride (TG), non-esterified fatty acid (NEFA), cholesterol at baseline and after 14 d, the dose of YM268 for exhibiting a 30% decrease in each parameter (ED(30)).RESULTS: Insulin, TG, and NEFA concentrations were approximately 2-6 times higher in obese rats. YM268 had no effect on glucose but decreased insulin in lean and obese rats with ED(30) of 3.0 and 2.9 mg/kg. YM268 also reduced TG and NEFA in lean and obese rats [ED(30) (mg/kg): lean; 4.1 (TG), 5.0 (NEFA), obese; 2.1, 3.0]. A significant correlation of either TG or NEFA level to insulin was established in lean and obese rats.CONCLUSION: Plasma TG and NEFA, but not cholesterol concentration, are dependent on plasma insulin in lean and obese Zucker rats, and insulin sensitivity with respect to TG and NEFA metabolism in obese rats may not be different from that in lean rats.