Nanotechnology in the diagnosis and treatment of stroke.
Nanotechnology in the diagnosis and treatment of stroke.
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DOI：
10.1016/j.drudis.2020.11.018
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发表时间：
2020-11
影响因子：
7.4
通讯作者：
Deepaneeta Sarmah;Mainak Banerjee;Aishika Datta;K. Kalia;S. Dhar;D. Yavagal;P. Bhattacharya
中科院分区：
文献类型：
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作者：
Deepaneeta Sarmah;Mainak Banerjee;Aishika Datta;K. Kalia;S. Dhar;D. Yavagal;P. Bhattacharya
纳米技术不仅为中风治疗药物的输送打开了一扇新的窗口，而且改善和简化了中风的诊断。由金、氧化铁、全氟碳、聚合物和量子点制成的纳米颗粒可能被广泛用于中风的诊断和治疗。纳米粒子的生物相容性和安全性问题可以通过结构修饰或涂层来克服和增强。纳米技术领域的不断发展已经点燃了其在中风诊断和治疗中的应用。结构修饰、易于合成和生物相容性的优点支持了纳米材料在临床中的应用。中风的病理生理是复杂的，涉及不同的大脑区域；因此，治疗剂需要被输送到特定的区域。纳米颗粒（NPs）可以被设计成帮助改善局部方式的治疗药物的输送和释放，特别是在半影区。这不仅有助于治疗，也有助于神经外科和神经影像学。纳米材料的疗效高，副作用少。在这篇综述中，我们提供了一个关于纳米技术在中风治疗和诊断方面的注意事项的简明总结。
HighlightsNanotechnology has not only opened a new window for the delivery of drugs for stroke therapy but also has improved and eased stroke diagnosis.Nanoparticles made from gold, iron oxide, perfluorocarbon, polymers and quantum dots may be robustly employed for stroke diagnosis and therapy.Biocompatibility and safety concerns of nanoparticles may be overcome and enhanced by structural modification or by coating.Increasing developments in the field of nanotechnology have ignited its use in stroke diagnosis and treatment. The benefits of structural modification, ease of synthesis, and biocompatibility support the use of nanomaterials in the clinic. The pathophysiology of stroke is complex, involving different brain regions; hence, therapeutic agents are required to be delivered to specific regions. Nanoparticles (NPs) can be engineered to help improve the delivery and release of therapeutic agents in a localized manner, especially in the penumbra. This contributes not only to therapy, but also to neurosurgery and neuroimaging. Nanomaterials also offer high efficacy with few adverse effects. In this review, we provide a concise summary of the caveats associated with nanotechnology with respect to stroke therapy and diagnosis.