Serum 25-Hydroxyvitamin D, Albumin, and Mortality Among Chinese Older Adults: A Population-based Longitudinal Study
Serum 25-Hydroxyvitamin D, Albumin, and Mortality Among Chinese Older Adults: A Population-based Longitudinal Study
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中国老年人血清 25-羟基维生素 D、白蛋白与死亡率：基于人群的纵向研究
DOI：
10.1210/clinem/dgaa349
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发表时间：
2020-08-01
影响因子：
5.8
通讯作者：
Yao, Yao
中科院分区：
文献类型：
--
作者：
Jin, Xurui;Xiong, Shangzhi;Yao, Yao
内容：血清25-羟基维生素D浓度[25（OH）D]与全因死亡率之间的关系在现有文献中不一致。一个合理的原因是内在维生素D与其他生物条件如营养不良和慢性inflammation.Objective的相互作用：探讨血清25（OH）D水平，白蛋白和全因死亡率之间的关系，并进一步评估它们在老年人中的相互作用。设计：基于人群的纵向研究。数据来自1834名年龄在65至112岁之间的人，他们在2011年基线时测定了血清25（OH）D和白蛋白。在2014年和2018年的随访调查波中确定了参与者的生存状态。主要结果测量：全因死亡率。结果：在1834名参与者中，血清25（OH）D和白蛋白浓度与全因死亡率呈负相关（Ps <0. 001）。此外，在参与者中观察到25（OH）D和白蛋白对全因死亡率的交互作用（P = 0.001）。在白蛋白水平较高的组（>= 40 g/L）中，25（OH）D水平较低的参与者（
Context: The associations between serum 25-hydroxyvitamin D concentrations [25(OH)D] and all-cause mortality have been inconsistent in existing literatures. One plausible reason is the interaction of intrinsic vitamin D with other biological conditions such as malnutrition and chronic inflammation.Objective: To explore the associations between serum levels of 25(OH)D, albumin, and all-cause mortality and further evaluate their interactions in elderly people.Design: Population-based longitudinal study.Setting and Participants: Data were obtained from 1834 people aged 65 to 112 who had their serum 25(OH)D and albumin assayed at baseline in 2011. Participants' survival status was ascertained at the 2014 and 2018 follow-up survey waves.Main Outcome Measures: All-cause mortality.Results: Among the 1834 participants, both serum 25(OH)D and albumin concentrations were inversely associated with all-cause mortality (Ps < 0.001). In addition, the interaction effect of 25(OH)D and albumin on all-cause mortality was observed among the participants (P = 0.001). In the group with a higher albumin level (>= 40 g/L), participants with a lower level of 25(OH) D (