Intracochlear pressure and derived quantities from a three-dimensional model.
Intracochlear pressure and derived quantities from a three-dimensional model.
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DOI：
10.1121/1.2747162
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发表时间：
2007-07
期刊：
影响因子：
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通讯作者：
Yong-Jin Yoon;S. Puria;C. Steele
中科院分区：
文献类型：
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作者：
Yong-Jin Yoon;S. Puria;C. Steele
颅内压计算从生理基础上，三维沙鼠耳蜗模型。Olson [J. Acoust. Soc. Am. 103，3445-3463（1998）; 110，349-367（2001）]测量了沙鼠颅内压，并提供了以下导出量的近似值：（1）基底膜速度，（2）穿过Corti器官的压力，和（3）分区阻抗。这项工作的目的是比较点处压力的计算和测量以及推导出的量。该模型包括三维粘性流体和弹性正交各向异性基底膜的梳状区，其尺寸和材料性质沿其长度沿着变化。通过将前馈近似添加到被动模型中，将Corti细胞结构器官内的外毛细胞力的布置并入，如前所述。颅内压由压缩快波和慢行波组成。一个Wentzel-Kramers-Brillowin渐近和数值方法相结合的傅立叶级数展开，提供了一个有效的程序，需要约1秒来计算一个给定的频率的响应。结果表明，直接压力和导出的量相当好的协议。这证实了流体的三维运动对于准确的耳蜗模型的重要性。
Intracochlear pressure is calculated from a physiologically based, three-dimensional gerbil cochlea model. Olson [J. Acoust. Soc. Am. 103, 3445-3463 (1998); 110, 349-367 (2001)] measured gerbil intracochlear pressure and provided approximations for the following derived quantities: (1) basilar membrane velocity, (2) pressure across the organ of Corti, and (3) partition impedance. The objective of this work is to compare the calculations and measurements for the pressure at points and the derived quantities. The model includes the three-dimensional viscous fluid and the pectinate zone of the elastic orthotropic basilar membrane with dimensional and material property variation along its length. The arrangement of outer hair cell forces within the organ of Corti cytoarchitecture is incorporated by adding the feed-forward approximation to the passive model as done previously. The intracochlear pressure consists of both the compressive fast wave and the slow traveling wave. A Wentzel-Kramers-Brillowin asymptotic and numerical method combined with Fourier series expansions is used to provide an efficient procedure that requires about 1 s to compute the response for a given frequency. Results show reasonably good agreement for the direct pressure and the derived quantities. This confirms the importance of the three-dimensional motion of the fluid for an accurate cochlear model.