Selective inhibition of microcirculation in tumor tissue
Selective inhibition of microcirculation in tumor tissue
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选择性抑制肿瘤组织微循环
DOI：
10.1007/bf01073629
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
P. G. Reitnauer
中科院分区：
文献类型：
--
作者：
M. Ardenne;P. G. Reitnauer
在以前的文献[1，2]中，我们可以证明，组织酸化和热疗是癌症多步治疗的主要步骤[3]，它显著或几乎完全抑制了肿瘤组织的微循环。我们最近改进了其他地方描述的更详细的方法[1]，证实了以前的结果，并将我们的研究扩大到总共150只大鼠[4]。将去除结缔组织和坏死部分的小片DS癌肉瘤注射到Wistar大鼠右后腿的股腹侧区域。荷瘤动物的体重从4g到25g不等。大鼠麻醉后背部固定于板凳上。一束红光通过屏蔽的玻璃棒被引导到组织中
In previous papers [1, 2] we could show that tissue acidification and hyperthermia, the main steps of the cancer multistep therapy [3], inhibit microcirculation in tumor tissues markedly or almost completely. We have recently improved the method described elsewhere in more detail [1], confirmed the former results, and expanded our studies to a total of 150 rats [4].Small pieces of DS carcinosarcoma free from connective tissues and necrotic parts were injected sc into the regio femoris ventralis of the right hind legs of Wistar rats. Animals bearing tumors ranging from 4 to 25 g were used for the experiments. The rats were anesthetized and fixed in dorsal position on a bench. A beam of red light () o> 600 nm) was conducted into the tissues by means of a glass rod shielded