Genetic analysis of a factor regulating melanogenesis in the mouse melanocyte.
Genetic analysis of a factor regulating melanogenesis in the mouse melanocyte.
复制标题
调节小鼠黑素细胞黑素生成的因子的遗传分析。
DOI：
10.1266/jjg.43.249
复制
发表时间：
1968
期刊：
影响因子：
--
通讯作者：
T. Takeuchi
中科院分区：
文献类型：
--
作者：
T. Takeuchi
1)在小鼠中，多巴氧化酶反应阳性的黑色素母细胞出现在新生小鼠的表皮基底层，但在成年小鼠的表皮中检测不到。2)两个品系的单位面积上多巴阳性的黑色素母细胞的数量在两个品系之间存在显著差异。C3H/HeNSa和C57BL/6.3)的差异似乎归因于显微分光光度法测定的两个品系的表皮黑素母细胞的多巴氧化酶活性的差异。4)两个品系正反交的F1在多巴阳性细胞数和细胞酶活性方面都表现出中间值。5)F2多巴阳性细胞的数量分布相当广泛。6)这些结果似乎表明抑制因子参与了多巴氧化酶活性的品系差异，并受两个以上的基因控制。
1) In the mouse, melanoblasts positive to the dopa-oxidase reaction appear in the basal layer of the epidermis at neo-natal stages, though they can not be detected in the epidermis of adult mice.2) There was a significant difference in the number of the dopa-positive melanoblasts per unit area of the epidermis at the neo-natal stages between the two strains examined, C3H/HeNSa and C57BL/6.3) The difference seems to be attributable to the difference in dopa-oxidase activity of the epidermal melanoblasts from the two strains as determined microspectrophotometrically.4) The F1 from the reciprocal crosses between the two strains exhibited an intermediate value in both the number of dopa-positive cells and the enzyme activity of the cells.5) The F2 showed a considerably wider distribution in the number of dopa-positive cells.6) These results seem to suggest an inhibitory factor is involved in the strain difference in the dopa-oxidase activity and is controlled by more than two loci.