Hepatoprotective effect of Hovenia dulcis Thunb on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide
Hepatoprotective effect of Hovenia dulcis Thunb on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide
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DOI：
10.1248/bpb.20.381
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发表时间：
1997-04-01
影响因子：
2
通讯作者：
Namba, T
中科院分区：
文献类型：
--
作者：
Hase, K;Ohsugi, M;Namba, T
木豆果实的保肝作用。对化学或免疫诱导的实验性肝损伤模型进行检测。甲醇提取物对大鼠CCl_4毒性和D-氨基半乳糖(D-GalN)/脂多糖诱导的小鼠肝损伤有明显的保护作用。甲醇提取物对原代培养大鼠肝细胞的CCl_4毒性也有明显的保护作用。保肝活性导向的分离和化学分析导致从甲醇提取物中分离出活性成分(+)-蛇葡萄素(1)。
The hepatoprotective effects of the fruits of Hovenia dulcis THUNB. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (D-GalN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl4-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent, (+)-ampelopsin (1) from the methanol extract.