Associations of human leucocyte antigen class II-DQB1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family-based study
Associations of human leucocyte antigen class II-DQB1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family-based study
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DOI：
10.1111/jvh.12573
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发表时间：
2016-12-01
影响因子：
2.5
通讯作者：
El-Waseef, A.
中科院分区：
文献类型：
--
作者：
El-Bendary, M.;Neamatallah, M.;El-Waseef, A.
丙型肝炎感染是一种全球流行病。 HLA-DQB1 等位基因被认为在针对 HCV 的免疫反应中具有有效作用，包括对这种感染的易感性或保护作用。本研究的目的是通过基于家庭的关联研究来调查 HLA-DQB1 等位基因在 HCV 基因型 4 感染结果中的贡献。本研究招募了埃及 HCV 家庭 (324)（324 个 RNA-HCV 指数呈阳性，225 个代表慢性丙型肝炎病例的阳性亲属，582 个 HCV-RNA 阴性家庭成员[对照]，其中 63 人自发清除了病毒。所有受试者均通过序列特异性引物 (SSP-PCR) 和基于序列的分型 (SBT) 方法对 HLA-DQB1 等位基因进行基因分型。与对照组和自发清除病毒的患者相比，感染患者的 DQB1*02:01:01 携带率显着更高（OR=5.47，P
Hepatitis C infection is a global pandemic. HLA-DQB1 alleles are believed to have an effective role in immune response against HCV including susceptibility to or protection from this infection. The aim of this study was to investigate the contribution of HLA-DQB1 alleles in the outcome of HCV genotype-4 infection through a family-based association study. Egyptian families with HCV (324) were recruited for this study (324 index positive for RNA-HCV, 225 positive relatives representing chronic hepatitis C cases and 582 family members negative for HCV-RNA [control], 63 of whom spontaneously cleared the virus. All subjects were genotyped for HLA-DQB1 alleles by sequence-specific primers (SSP-PCR) and sequence-based typing (SBT) methods. The frequency of DQB1*02:01:01 carriage was significantly higher in infected patients when compared to controls and those who spontaneously cleared virus (OR=5.47, P