Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development
Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development
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DOI：
10.1016/s0925-4773(00)00259-8
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发表时间：
2000-05-01
影响因子：
2.6
通讯作者：
Delabar, JM
中科院分区：
文献类型：
--
作者：
Rachidi, M;Lopes, C;Delabar, JM
TPRD基因（tetratricopeptide，TPR）是唐氏综合征染色体1区的候选基因之一。该基因的重复可能是唐氏综合征主要表型特征的原因。在这里，我们表明，TPRD的表达在人类胚胎发育过程中发育调节。在发育的最早阶段（Camegie 8-12），TPRD表达普遍存在。在后来的发育阶段（卡内基阶段14，16和18），它变得局限于神经系统，就像在小鼠发育过程中的mtprd基因一样。我们扩展了我们的分析TPRD表达在胎儿发育的人神经系统（13，22和24周）。一种新的斜照明技术被用来比较信号强度和细胞密度。神经系统的一些区域，如大脑的外部皮质层和眼睛的内部成神经细胞层，强烈表达TPRD基因。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
The TPRD gene (tetratricopeptide (TPR) containing Down syndrome gene) is one of the candidate genes in the Down syndrome chromosomal region-1. Duplication of this gene may be the cause of major phenotypic features of Down syndrome. Here we show that the TPRD expression is developmentally regulated during human embryogenesis. At the earliest stages of development (Camegie 8-12) TPRD expression is ubiquitous. At later developmental stages (Carnegie stages 14, 16 and 18), it becomes restricted to the nervous system, as is the case for the mtprd gene during mouse development. We extended our analysis of TPRD expression during fetal development of the human nervous system (13, 22 and 24 weeks). A new oblique illumination technique was used to compare signal intensity and cell density. Some regions of the nervous system such as the external cortical layers of the brain, and the inner neuroblastic layer of the eye, strongly express the TPRD gene. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.