CD95/CD95 ligand-mediated counterattack does not block T cell cytotoxicity
CD95/CD95 ligand-mediated counterattack does not block T cell cytotoxicity
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DOI：
10.1006/bbrc.2000.2792
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发表时间：
2000-06-07
影响因子：
3.1
通讯作者：
Gulbins, E
中科院分区：
文献类型：
--
作者：
Jekle, A;Obst, R;Gulbins, E
CD95配体在实质细胞、上皮细胞或肿瘤细胞上的表达被认为下调免疫应答并控制淋巴细胞活化。抑制可能是通过诱导细胞凋亡或通过抑制CD95触发后的Ca 2+通道介导的。因此，我们的目的是采用这种模型来修改抗原呈递MC57细胞呈递给细胞毒性T细胞的抗原的免疫应答。该模型对于在自身免疫情况下特异性下调对自身抗原的免疫应答将是非常有用的。然而，在本研究中测试的细胞毒性T细胞系对抗原呈递MC57细胞上的CD95配体表达具有抗性。此外，淋巴细胞与抗原呈递细胞的共孵育未能阻断T淋巴细胞介导的细胞毒性。因此，我们得出结论，抗原呈递细胞上CD95配体的单一表达不足以特异性下调由CD8+触发的免疫应答。(C)北京大学出版社.
Expression of CD95 ligand on parenchymal, epithelial, or tumor cells has been suggested to downregulate the immune response and to control lymphocyte activation. Suppression might be mediated by induction of apoptosis or by inhibition of Ca2+ channels upon CD95 triggering. We, therefore, aimed to employ this model to modify the immune response to an antigen presented to cytotoxic T cells by antigen-presenting MC57 cells. This model would be very useful to specifically downregulate the immune response to autoantigens in autoimmune situations. However, cytotoxic T cell lines tested in the present study were resistant to CD95 ligand expression on antigen-presenting MC57 cells. In addition, coincubation of the lymphocytes with antigen presenting cells failed to block cytotoxicity mediated by the T lymphocytes. We, therefore, conclude that single expression of CD95 ligand on antigen-presenting cells is insufficient to specifically downregulate an immune response by CD8+- triggered immune response. (C) 2000 Academic Press.