Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons.
Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons.
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DOI：
10.1038/s41598-018-23855-9
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发表时间：
2018-04-03
影响因子：
4.6
通讯作者：
Cucinotta FA
中科院分区：
文献类型：
--
作者：
Cacao E;Parihar VK;Limoli CL;Cucinotta FA
与癌症放疗相关的认知功能障碍与多种因素相关，其中之一是神经元细胞树突形态的变化。树突几何形状和分支模式的改变通常伴随着影响学习和记忆的缺陷。本研究的目的是开发一种新的预测模型，用于预测因暴露于低线性能量转移 (LET) 辐射（例如 X 射线、γ 射线和高能质子）而引起的神经元树突损伤。我们建立了小鼠海马齿状颗粒细胞层 (GCL) 和 CA1 锥体神经元的计算机表征，这些神经元经常在辐射引起的认知衰退中进行检查。计算机表征用于随机模型，该模型描述了因暴露于低 LET 辐射而引起的时间依赖性树突损伤。该模型描述了形态参数的变化，例如树突总长度、分支点数量和分支数量，包括单个神经元的 Sholl 分析。我们基于树突段 (EDDS) 能量沉积的模型对不同形态变化模式的预测将作为比较 EDDS 机制引起的形态变化的特定模式的有用基础。
Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and memory. The purpose of this study is to develop a novel predictive model of neuronal dendritic damages caused by exposure to low linear energy transfer (LET) radiation, such as X-rays, γ-rays and high-energy protons. We established in silico representations of mouse hippocampal dentate granule cell layer (GCL) and CA1 pyramidal neurons, which are frequently examined in radiation-induced cognitive decrements. The in silico representations are used in a stochastic model that describes time dependent dendritic damage induced by exposure to low LET radiation. Changes in morphometric parameters, such as total dendritic length, number of branch points and branch number, including the Sholl analysis for single neurons are described by the model. Our model based predictions for different patterns of morphological changes based on energy deposition in dendritic segments (EDDS) will serve as a useful basis to compare specific patterns of morphological alterations caused by EDDS mechanisms.
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影响因子：
4.6
作者：
Acharya MM;Green KN;Allen BD;Najafi AR;Syage A;Minasyan H;Le MT;Kawashita T;Giedzinski E;Parihar VK;West BL;Baulch JE;Limoli CL
通讯作者：
Limoli CL
DOI：
10.1158/1078-0432.ccr-11-2903
发表时间：
2013-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Greene-Schloesser D;Moore E;Robbins ME
通讯作者：
Robbins ME
影响因子：
4.7
作者：
Greene-Schloesser D;Robbins ME;Peiffer AM;Shaw EG;Wheeler KT;Chan MD
通讯作者：
Chan MD
影响因子：
4.3
作者：
Alp, Murat;Parihar, Vipan K.;Cucinotta, Francis A.
通讯作者：
Cucinotta, Francis A.
DOI：
10.1242/dev.081315
发表时间：
2012-09
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Fujishima K;Horie R;Mochizuki A;Kengaku M
通讯作者：
Kengaku M