Spectrotemporal analysis of evoked and induced electroencephalographic responses in primary auditory cortex (A1) of the awake monkey
Spectrotemporal analysis of evoked and induced electroencephalographic responses in primary auditory cortex (A1) of the awake monkey
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DOI：
10.1093/cercor/bhm094
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发表时间：
2008-03-01
期刊：
影响因子：
3.7
通讯作者：
Arezzo, Joseph C.
中科院分区：
文献类型：
--
作者：
Steinschneider, Mitchell;Fishman, Yonatan I.;Arezzo, Joseph C.
脑电描记术正越来越多地被用于探索听觉皮层的功能组织。在清醒猴初级听皮层（A1）观察了声调对脑电信号的调制作用。EEG数据在由最佳频率（BF）音诱发的电流源密度分布定义的4个层流深度处测量。中层多单元活动被用来定义A1网站的调谐特性。BF音的呈现在检查的频率范围内（4-290 Hz）增加了EEG功率，在刺激开始后的前100 ms内最大效果明显。EEG功率的最大相对增加通常发生在非常高的伽马频带（130-210 Hz）。频率低于70 Hz时EEG功率的增加主要代表锁相活动的变化，而频率较高时的增加主要代表非锁相活动的变化。在较高的伽玛波段的功率增加更好地与A1 tonotopic组织比功率增加在较低的频带。检查的4个椎板深度的结果相似。这些发现强调了检查高频EEG成分在探索听觉皮层功能组织中的价值，并可能增强对人类相关研究的解释。
Electroencephalography is increasingly being used to probe the functional organization of auditory cortex. Modulation of the electroencephalographic (EEG) signal by tones was examined in primary auditory cortex (A1) of awake monkeys. EEG data were measured at 4 laminar depths defined by current source density profiles evoked by best frequency (BF) tones. Midlaminar multiunit activity was used to define the tuning characteristics of A1 sites. Presentation of BF tones increased EEG power across the range of frequencies examined (4-290 Hz), with maximal effects evident within the first 100 ms after stimulus onset. The largest relative increases in EEG power generally occurred at very high gamma frequency bands (130-210 Hz). Increases in EEG power for frequencies less than 70 Hz primarily represented changes in phase-locked activity, whereas increases at higher frequencies primarily represented changes in non-phase-locked activity. Power increases in higher gamma bands were better correlated with the A1 tonotopic organization than power increases in lower frequency bands. Results were similar across the 4 laminar depths examined. These findings highlight the value of examining high-frequency EEG components in exploring the functional organization of auditory cortex and may enhance interpretation of related studies in humans.