Relationship between monocyte to HDL cholesterol ratio and concomitant cardiovascular disease in Chinese Han patients with obstructive sleep apnea
Relationship between monocyte to HDL cholesterol ratio and concomitant cardiovascular disease in Chinese Han patients with obstructive sleep apnea
复制标题
中国汉族阻塞性睡眠呼吸暂停患者单核细胞与HDL胆固醇比值与合并心血管疾病的关系
DOI：
10.21037/cdt.2019.08.02
复制
发表时间：
2019-08-01
影响因子：
2.4
通讯作者：
Li, Qing Yun
中科院分区：
文献类型：
--
作者：
Li, Ning;Ren, Lei;Li, Qing Yun
背景资料：阻塞性睡眠呼吸暂停（OSA）是心血管疾病（CVD）的独立危险因素，其归因于慢性间歇性缺氧（CIH）诱导的炎症反应。单核细胞与高密度脂蛋白胆固醇比值（MHR）作为一种新的心血管疾病炎症标志物，在OSA研究中尚未引起足够的重视。因此，我们的目的是调查中国男性OSA患者中MHR与伴随CVD之间的相关性。方法：共有657名中国汉族受试者（169名对照，145名轻度，94名中度和249名重度OSA）参加了这项横断面研究，平均BMI为32.35 +/- 6.56 kg/m2。结果：MHR水平与呼吸暂停低通气指数（AHI）呈正相关，与最低SpO（2）呈负相关（P
Background: Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease (CVD), which is attributed to chronic intermittent hypoxia (CIH) induced inflammation. As a new inflammatory biomarker of CVD, monocyte to high-density lipoprotein cholesterol ratio (MHR) has received little attention in OSA studies to date. Therefore, we aimed to investigate the correlation between MHR and concomitant CVD in Chinese Man patients with OSA.Methods: A total of 657 Chinese Han subjects (169 controls, 145 mild, 94 moderate, and 249 severe OSA) of both genders were enrolled in this cross-sectional study, with an average BMI of 32.35 +/- 6.56 kg/m(2). The relationship between MHR and concomitant CVD in OSA patients was analyzed.Results: The level of MHR was correlated positively with apnea-hypopnea index (AHI), while negatively with lowest SpO(2) (P