Distribution of inhaled volatile turmerones in the mouse
Distribution of inhaled volatile turmerones in the mouse
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DOI：
10.1016/j.fbio.2021.100965
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发表时间：
2021-03-10
期刊：
影响因子：
5.2
通讯作者：
Zaima, Nobuhiro
中科院分区：
文献类型：
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作者：
Takemoto, Yuki;Sumi, Tomoko;Zaima, Nobuhiro
姜黄酮(α-姜黄酮、β-姜黄酮和姜黄酮)是姜黄中的主要生物活性成分，在亚洲被用作草药。姜黄酮的显著特点是味道浓郁，这归因于它们的挥发性。据报告，口服姜黄酮在器官中以完整的形式分布；然而，吸入挥发性姜黄酮在体内的分布仍不清楚。本研究旨在估计吸入挥发性姜黄酮的分布。在小鼠暴露于挥发性姜黄油后，在肺、嗅球、脑、血清、心脏、肝脏、肾脏、附睾脂和棕色脂肪组织中发现了姜黄酮。每种姜黄酮在不同器官中的浓度范围不同：α-姜黄酮(5.74-425 ng/kg)、β-姜黄酮(6.41-231 ng/kg)和α-姜黄酮(61.0-594 ng/kg)。这些结果表明，挥发性姜黄酮可以结合到动物体内，每个器官的浓度范围不同。
Turmerones (alpha-turmerone, beta-turmerone, and ar-turmerone), the main bioactive compounds in turmeric (Curcuma longa), are used as herbal medicines in Asia. The distinct feature of turmerones is their strong flavor, which is attributed to their volatility. Orally administered turmerones are reportedly distributed in their intact forms in organs; however, the distribution of inhaled volatile turmerones in the body remains unknown. This study aimed to estimate the distribution of inhaled volatile turmerones. After mice were exposed to volatile turmeric oil, turmerones were found in the lung, olfactory bulb, brain, serum, heart, liver, kidney, epididymal fat, and brown adipose tissue. Each turmerone had a different range of concentrations in the different organs: alpha-turmerone (5.74-425 ng/kg), beta-turmerone (6.41-231 ng/kg), and ar-turmerone (61.0-594 ng/kg). These results suggested that volatile turmerones could be incorporated into the animal body with a distinct range of concentration for each organ.