Synthesis, characterization, and anticancer activity of a series of ketone-N(4)-substituted thiosemicarbazones and their ruthenium(II) arene complexes.
Synthesis, characterization, and anticancer activity of a series of ketone-N(4)-substituted thiosemicarbazones and their ruthenium(II) arene complexes.
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DOI：
10.1021/ic401362s
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发表时间：
2013-10
影响因子：
4.6
通讯作者：
Wei Su;Quanquan Qian;Peiyuan Li;Xiaoling Lei;Qi Xiao;Sha-Hua Huang;Chusheng Huang;Jianguo Cui
中科院分区：
文献类型：
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作者：
Wei Su;Quanquan Qian;Peiyuan Li;Xiaoling Lei;Qi Xiao;Sha-Hua Huang;Chusheng Huang;Jianguo Cui
合成了一系列酮-N（4）-取代缩氨基硫脲（TSC）化合物（L1-L9）及其相应的[（η（6）-对伞花烃）Ru（II）（TSC）Cl]（+/0）配合物（1-9），并通过NMR、IR、元素分析和HR-ESI-MS进行了表征。通过单晶X射线衍射分析确定了L4、L9、1-6和9的分子结构。进一步评价化合物对SGC-7901人胃癌、BEL-7404人肝癌和HEK-293 T非癌细胞系的体外抗增殖活性。此外，化合物与DNA的相互作用，其次是电泳迁移谱研究。
A series of ketone-N(4)-substituted thiosemicarbazone (TSC) compounds (L1-L9) and their corresponding [(η(6)-p-cymene)Ru(II)(TSC)Cl](+/0) complexes (1-9) were synthesized and characterized by NMR, IR, elemental analysis, and HR-ESI-mass spectrometry. The molecular structures of L4, L9, 1-6, and 9 were determined by single-crystal X-ray diffraction analysis. The compounds were further evaluated for their in vitro antiproliferative activities against the SGC-7901 human gastric cancer, BEL-7404 human liver cancer, and HEK-293T noncancerous cell lines. Furthermore, the interactions of the compounds with DNA were followed by electrophoretic mobility spectrometry studies.