Therapeutic capacity of the synthetic peptide-based vaccine against Taenia solium cysticercosis in pigs
Therapeutic capacity of the synthetic peptide-based vaccine against Taenia solium cysticercosis in pigs
复制标题
DOI：
10.1016/j.vaccine.2004.11.076
复制
发表时间：
2005-07-01
期刊：
影响因子：
5.5
通讯作者：
Sciutto, E
中科院分区：
文献类型：
--
作者：
de Aluja, AS;Villalobos, NM;Sciutto, E
由三种肽（GK1、KETc1和KETc12）组成的S3Pvac合成疫苗可有效预防猪囊尾蚴病。初步结果表明，S3Pvac 或 GK1 免疫诱导了额外的杀囊能力。提供了 S3Pvac 而非 GK1 的杀囊作用的明确证据。对已经实验感染的猪进行 S3Pvac 免疫，可导致寄生虫负载、水泡囊尾蚴及其活力减少。它还显着增加了组织学损伤的囊尾蚴的百分比，更重要的是在肌肉中而不是在大脑中。伴随着抗体水平的降低，因此。 S3Pvac 是控制猪囊尾蚴病感染的有力手段。 (c) 2005 年，爱思唯尔有限公司出版。
The S3Pvac synthetic vaccine composed of three peptides (GK1. KETc1 and KETc12) effectively protect against pig cysticercosis. Preliminary results point to an additional cysticidal capacity induced by S3Pvac or GK1 immunization, Herein. clear evidences of the cysticidal effect of S3Pvac but not of GK1 are presented. S3Pvac immunization of already experimentally infected pigs induced a reduction in the parasite load, in the vesicular cysticerci and in their viability. It also substantially increases the percent of histological damaged cysticerci more importantly in muscles than in brains. with a concomitant reduction in the antibody levels, Thus. S3Pvac represents a powerful means of controlling cysticercosis infection in pigs. (c) 2005 Published by Elsevier Ltd.