Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions
Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions
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DOI：
10.1128/jvi.00904-15
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发表时间：
2016-06-01
影响因子：
5.4
通讯作者：
Smith, Jason G.
中科院分区：
文献类型：
--
作者：
Wilson, Sarah S.;Wiens, Mayim E.;Smith, Jason G.
防御素是在整个人体粘膜表面表达的先天免疫效应肽，在体外具有有效的抗病毒作用。防御素在体内病毒发病机制中的作用尚不清楚。然而，最近的研究表明，防御素-病毒在体内的相互作用是复杂的，并且与它们提出的体外抗病毒机制不同。这些发现强调需要进行额外的研究，将细胞培养物中病毒的防御素中和与体内抗病毒机制联系起来。
Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro. The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus interactions in vivo are complicated and distinct from their proposed antiviral mechanisms in vitro. These findings highlight the need for additional research that connects defensin neutralization of viruses in cell culture to in vivo antiviral mechanisms.