Bacterial flora of ex-germfree mice after oral inoculation of feces from various species of conventional animals.
Bacterial flora of ex-germfree mice after oral inoculation of feces from various species of conventional animals.
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经口接种各种常规动物粪便后的无菌小鼠的细菌菌群。
DOI：
10.1538/expanim1978.30.2_157
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
T. Kurosawa
中科院分区：
文献类型：
--
作者：
K. Maejima;J. Sasaki;K. Shimoda;T. Kurosawa
将常规小鼠、兔、狗或食蟹猴的新鲜粪便乳剂口服给无菌和常规ICR小鼠。在接种前无菌小鼠身上建立了各种在模式上与接种剂中的粪便菌群惊人相似的粪便菌群。用最初接种(常规化)后21天制成的常规小鼠的粪便乳剂重新接种这些无菌小鼠，会导致它们的菌群改变为传统小鼠的固有模式。来自不同物种的传统动物的粪便给药并没有明显改变传统小鼠的粪便菌群。结果表明，动物肠道菌群在第一阶段是由污染物的肠道菌群决定的，但后来在各种宿主因素的主导影响下，这种菌群会发生变化。
Emulsions of fresh feces from a conventional mouse, rabbit, dog or cynomolgus monkey were administered orally to germfree and conventional ICR mice. Various fecal floras bearing a striking resemblance in pattern to those in the inoculant became established in the inoculated ex-germfree mice. Reinoculation of these ex-germfree mice with fecal emulsions from a conventional mouse made 21 days after the original inoculation (conventionalization) led to alteration of their floras to the indigenous pattern of conventional mice. The administration of feces from the conventional animals of different species did not appreciably modify the fecal flora of conventional mice. The results indicate that intestinal flora of animals is determined in the first stage by that of the contaminants, but this would be altered later under the predominant influence of the various host factors.