Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis.
Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis.
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DOI：
10.1016/j.jhep.2015.08.022
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发表时间：
2016-01
影响因子：
25.7
通讯作者：
Rector RS
中科院分区：
文献类型：
--
作者：
Sheldon RD;Nicole Blaize A;Fletcher JA;Pearson KJ;Donkin SS;Newcomer SC;Rector RS
Mounting evidence indicates that maternal exercise confers protection to adult offspring against various diseases. Here we hypothesized that maternal exercise during gestation would reduce high fat diet (HFD) induced hepatic steatosis in adult rat offspring. Following conception, pregnant dams were divided into either voluntary wheel running exercise (GE) or wheel-locked sedentary (GS) groups throughout gestation (days 4-21). Post-weaning, offspring received either normal chow diet (ND; 10% fat, 70% carbohydrate, 20% protein) or high-fat diet (HFD; 45% fat, 35% carbohydrate, and 20% protein) until sacrifice at 4-or 8-months of age. GE did not affect offspring birth weight or litter size. HFD feeding in offspring increased weight gain, % body fat, and glucose tolerance test area under the curve (GTT-AUC). Male offspring from GE dams had reduced % body fat across all ages (p < 0.05). In addition, 8-mo male offspring from GE dams were protected against HFD-induced hepatic steatosis, which was associated with increased markers of hepatic mitochondrial biogenesis (PGC-1α and TFAM), autophagic potential (ATG12:ATG5 conjugation) and hepatic triacylglycerol secretion (MTTP). The current study provides the first evidence that gestational exercise can reduce susceptibility to high fat diet induced hepatic steatosis in adult male offspring.
