Assessing the effect of 5-hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin
Assessing the effect of 5-hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin
复制标题
DOI：
10.1002/jsfa.8261
复制
发表时间：
2017-09-01
影响因子：
4.1
通讯作者：
Saleh-Ghadimi, Sevda
中科院分区：
文献类型：
--
作者：
Alizadeh, Mohammad;Khodaei, Hamed;Saleh-Ghadimi, Sevda
5-羟甲基糠醛（5-HMF）是美拉德反应的重要产物之一。近年来，该化合物的许多有益的生物学效应已被证明。本研究旨在通过研究卵清蛋白（OVA）免疫BALB/c小鼠的免疫应答中的一些选择性成分来阐明5-HMF的抗过敏作用。与对照组相比，5-HMF免疫动物的血清总抗体和OVA特异性抗体水平升高结果表明，5-HMF能显著抑制OVA引起的血清IgE和特异性IgE水平的升高（P < 0.05）。结论5-HMF通过抑制免疫BALB/c小鼠的Th 2型免疫应答，抑制总IgE和OVA特异性IgE的上调。5-因此，HMF可能是一种新的治疗方法，用于预防IgE介导的过敏性疾病。(c)2017年化学工业协会
BACKGROUND5-Hydroxymethylfurfural (5-HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti-allergic effect of 5-HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA).RESULTSImmunised animals had an increased level of serum total and OVA-specific antibodies when compared to the control (P < 0.01).We found that the OVA-induced increase in serum IgE and OVA-specific IgE were significantly suppressed in the groups treated with 5-HMF (P < 0.05). Moreover, interleukin-4 (IL-4) and interferon gamma (IFN-) were significantly reduced in a dose-independent manner when compared to the sensitised group (P < 0.05).CONCLUSION5-HMF inhibited the up-regulation of total and OVA-specific IgE through the suppression of the Th2-type immune response in immunised BALB/c mice. 5-HMF could therefore be a novel therapeutic approach for the prevention of IgE-mediated allergic diseases. (c) 2017 Society of Chemical Industry