Genetics of age-related macular degeneration.
Genetics of age-related macular degeneration.
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DOI：
10.1016/s0896-1549(03)00063-4
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发表时间：
2003-12-01
期刊：
影响因子：
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通讯作者：
Francis, Peter J
中科院分区：
文献类型：
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作者：
Klein, Michael L;Francis, Peter J
基因的发现将导致更有效的他们馅饼为AMD通过确定具体的潜在的疾病机制，可能会纠正药物或基因治疗。例如，目前正在使用色素上皮衍生因子（FEDF）进行研究。这种有效的血管生成抑制剂的基因已被整合到腺病毒载体中，并通过玻璃体内注射递送到眼睛中，以抑制患有新生血管性AMD的眼睛中新血管的生长。在未来，随着这种复杂疾病的遗传学被揭开，可以预期针对AMD发展的特定分子缺陷的更有效的治疗和预防措施。
Gene discoveries will lead to more effective them pies for AMD by identifying specific underlying disease mechanisms that might be corrected by drugs or gene therapy. For example, investigations are currently being carried out using pigment epithelium-derived factor (FEDF). The gene for this potent inhibitor of angiogenesis has been incorporated into an adenoviral vector and delivered into the eye by intravitreal injection to inhibit growth of new blood vessels in eyes with neovascular AMD. In the future, as the genetics of this complex disease are unraveled, more effective treatments and preventative measures that target specific molecular defects underlying the development of AMD can be expected.