Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: the effect of cetirizine and dimethindene
Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: the effect of cetirizine and dimethindene
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DOI：
10.1034/j.1398-9995.1999.00726.x
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发表时间：
1999-01-01
期刊：
影响因子：
12.4
通讯作者：
Kontou-Fili, K
中科院分区：
文献类型：
--
作者：
Borici-Mazi, R;Kouridakis, S;Kontou-Fili, K
背景：神经肽参与慢性荨麻疹的发病机制。本研究的目的是调查与健康成人（HA）相比，迟发性压力性荨麻疹患者（DPUpt）和慢性特发性荨麻疹患者（CIUpt）对P物质（SP）和降钙素基因相关肽（CGRP）的皮肤反应，并评估H-1拮抗剂对这些反应的影响。在注射后3、7、15、30、60和120 min，评价了9例CIUpt、9例DPUpt和9例HA对皮内（ID）注射SP、CGRP、组胺（H）和稀释剂对照的风团（W）和潮红（F）反应。在一项双盲、安慰剂对照（DBPC）、交叉、随机研究中，计算基线和单剂量西替利嗪（Ce）20 mg、二甲茚（Di）4 mg或安慰剂（P）4 h后的最大W和F、曲线下面积（AVC）以及W和F消失时间。
Background: Neuropeptides appear to participate in the pathogenesis of: chronic urticaria. The purpose of this study was to investigate the cutaneous responses to substance P (SP) and calcitonin gene-related peptide (CGRP) in delayed pressure urticaria patients (DPUpt) and chronic idiopathic urticaria patients (CIUpt) compared to healthy adults (HA), and also to evaluate the effect of H-1-antagonists on these responses.Methods: Wheal (W) and flare (F) reactions to intradermally (ID) injected SP, CGRP, histamine (H), and diluent controls were evaluated in nine CIUpt, nine DPUpt, and nine HA at 3, 7, 15, 30, 60, and 120 min after injection. Maximal W and F, area under curve (AVC), and time of W and F disappearance were calculated at baseline and 4 h after a single dose of 20 mg cetirizine (Ce), 4mg dimethindene (Di), or placebo (P), in a double-blind, placebo-controlled (DBPC), crossover, randomized study.Results: CIUpt exhibited enhanced and longer lasting W reactions to SP and CGRP (AUC: P