Fagomine isomers and glycosides from Xanthocercis zambesiaca.
Fagomine isomers and glycosides from Xanthocercis zambesiaca.
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DOI：
10.1021/np960646y
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发表时间：
1997-03
影响因子：
5.1
通讯作者：
A. Kato;N. Asano;H. Kizu;K. Matsui
中科院分区：
文献类型：
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作者：
A. Kato;N. Asano;H. Kizu;K. Matsui
对来自Xanthocercis zambesiaca（豆科植物）的叶和根的50%MeOH水溶液提取物进行各种离子交换柱色谱步骤，得到荞麦碱（1）、3-表荞麦碱（2）、3，4-二表荞麦碱（3）、3-O-β-D-吡喃葡萄糖基荞麦碱（4）和4-O-β-D-吡喃葡萄糖基荞麦碱（5）。通过光谱分析，特别是通过广泛的1D和2D NMR研究确定了它们的结构。化合物3和4为新的天然产物。化合物1是异麦芽糖酶和某些α-和β-半乳糖苷酶的良好抑制剂。而2是比1更有效的异麦芽糖酶和β-半乳糖苷酶抑制剂，它不抑制α-半乳糖苷酶。化合物3-5对所用的糖苷酶没有表现出显著的抑制作用。
50% aqueous MeOH extracts from the leaves and roots of Xanthocercis zambesiaca (Leguminosae) were subjected to various ion-exchange column chromatographic steps to give fagomine (1), 3-epi-fagomine (2), 3,4-di-epi-fagomine (3), 3-O-beta-D-glucopyranosylfagomine (4), and 4-O-beta-D-glucopyranosylfagomine (5). Their structures were determined by spectroscopic analyses, particularly by extensive 1D and 2D NMR studies. Compounds 3 and 4 are new natural products. Compound 1 is a good inhibitor of isomaltase and certain alpha- and beta-galactosidases. Whereas 2 is a more potent inhibitor of isomaltase and beta-galactosidases than 1, it does not inhibit alpha-galactosidase. Compounds 3-5 exhibited no significant inhibition against the glycosidases used.