Somatosensory contributions to c-fos activation within the caudal periaqueductal gray of lactating rats:: Effects of perioral, rooting, and suckling stimuli from pups
Somatosensory contributions to c-fos activation within the caudal periaqueductal gray of lactating rats:: Effects of perioral, rooting, and suckling stimuli from pups
复制标题
DOI：
10.1006/hbeh.1997.1416
复制
发表时间：
1997-12-01
影响因子：
3.5
通讯作者：
Stern, JM
中科院分区：
文献类型：
--
作者：
Lonstein, JS;Stern, JM
在哺乳期大鼠，立即早期基因c-fos先前被证明是高度激活的几个大脑部位的物理相互作用，无论是哺乳或nonsuckling小狗，但不是由远端刺激小狗，一个非小狗的刺激，或没有刺激。此外，甚至更高水平的Fos免疫反应性（ir）发生后，哺乳与非哺乳接触的幼崽在1个以上的25个网站-尾侧导水管周围灰质（cPAG）在丘间水平，病变严重减少了典型的哺乳诱导的后凸护理姿势。在此，我们进一步评估的影响和网站的特异性，各种体感线索收到的幼崽在60分钟内Fos-ir在产后第7天的大鼠FAG后，48小时母鼠-窝分离。与哺乳期与非哺乳期幼崽的Darns相互作用显示，在早期确定的丘间cPAG网站中Fos-ir细胞数量相对较高，但在FAG的其他三个吻尾平面中则没有。通过使用完全麻醉的幼犬消除在母鼠腹部的生根并没有进一步减少Fos-ir在母性行为，nonsuckled母鼠。母鼠在与窝仔团聚前的口周麻醉阻止了幼鼠的取回和舔舔，但未阻止幼鼠发起的哺乳行为，其持续时间与丘间cPAG内的Fos-ir水平呈正相关。因此，来自幼鼠的各种躯体感觉刺激激活c-fos在cPAG的离散区域，但只有包括哺乳及其行为后果的相互作用才能引起最大表达，这与大鼠后凸护理的感觉运动控制中该中脑部位的作用一致。(C)1997年学术出版社。
In lactating rats, the immediate-early gene c-fos was previously shown to be highly activated in several brain sites by physical interaction with either suckling or nonsuckling pups but not by distal stimuli from pups, a non-pup stimulus, or no stimulation. Further, even greater levels of Fos-immunoreactivity (ir) occurred following suckling versus nonsuckling contact with pups in only 1 of over 25 sites-the caudal periaqueductal gray (cPAG) at an intercollicular level, lesions of which severely reduced the typical suckling-induced kyphotic nursing posture. Herein we further evaluated the effects and site-specificity of various somatosensory cues received from pups during 60 min on Fos-ir in the FAG of day 7 postpartum rats after a 48-h dam-litter separation. Darns interacting with suckling versus nonsuckling pups showed relatively high numbers of Fos-ir cells in the intercollicular cPAG site identified earlier, but not in three other rostrocaudal planes of the FAG. Elimination of rooting on the dam's ventrum by use of fully anesthetized pups did not further diminish Fos-ir in maternally behaving, nonsuckled dams. Perioral anesthesia of dams prior to reunion with the litter prevented retrieval and licking of pups but not pup-initiated nursing behavior, the duration of which was positively correlated with Fos-ir levels within the intercollicular cPAG. Thus, various somatosensory stimuli from pups activate c-fos in a discrete region of the cPAG but only interactions that include suckling and its behavioral consequences elicit maximal expression, consistent with a role for this midbrain site in the sensorimotor control of kyphotic nursing in rats. (C) 1997 Academic Press.