A multimodal perspective on the composition of cortical oscillations.
A multimodal perspective on the composition of cortical oscillations.
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DOI：
10.3389/fnhum.2013.00132
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发表时间：
2013
影响因子：
2.9
通讯作者：
Hall SD
中科院分区：
文献类型：
--
作者：
Ronnqvist KC;McAllister CJ;Woodhall GL;Stanford IM;Hall SD
一个不断扩大的研究语料库详细介绍了功能性磁共振成像（fMRI）措施和神经元网络振荡之间的关系。通常，整合脑电图和功能磁共振成像，或并行脑磁图（MEG）和功能磁共振成像被用来推断BOLD和电测量的亲缘关系。然而，有一个相对缺乏的信息之间的关系E/MEG和这些信号的局灶性网络发出。因此，E/MEG振荡的成因和组成需要进一步澄清。在这里，我们的目标是通过一系列并行测量的初级运动皮层（M1）振荡，使用人类脑磁图和体外啮齿动物局部场电位的理解。我们比较自发活动在10 - 10 Hz mu和15-30 Hz β频率范围内，并比较MEG信号与独立和集成层III和V（LIII/LV）从体外记录。我们探索振荡产生的机制，使用特定的药理学调制与GABA-A α-1亚基调节剂唑吡坦。最后，为了确定皮质-皮质连接的贡献，我们在体外记录了M1，在切口切断M1和S1皮质之间的横向连接。我们证明，MEG信号的频率分布似乎有更密切的统计相似性，而不是独立的LIII/LV板层的综合信号。两种模式中的GABA能调节引起β带功率的可比变化。最后，感觉运动皮质（SMC）中的皮质-皮质连接似乎直接影响LIII中μ节律的功率。这些发现表明，MEG信号是LIII和LV输出的混合物，多个频率可以从相同的皮层区域产生，并且体外和MEG M1振荡由类似的机制驱动。最后，皮质-皮质连接反映在SMC μ节律的功率中。
An expanding corpus of research details the relationship between functional magnetic resonance imaging (fMRI) measures and neuronal network oscillations. Typically, integrated electroencephalography and fMRI, or parallel magnetoencephalography (MEG) and fMRI are used to draw inference about the consanguinity of BOLD and electrical measurements. However, there is a relative dearth of information about the relationship between E/MEG and the focal networks from which these signals emanate. Consequently, the genesis and composition of E/MEG oscillations requires further clarification. Here we aim to contribute to understanding through a series of parallel measurements of primary motor cortex (M1) oscillations, using human MEG and in vitro rodent local field potentials. We compare spontaneous activity in the ∼10 Hz mu and 15–30 Hz beta frequency ranges and compare MEG signals with independent and integrated layers III and V (LIII/LV) from in vitro recordings. We explore the mechanisms of oscillatory generation, using specific pharmacological modulation with the GABA-A alpha-1 subunit modulator zolpidem. Finally, to determine the contribution of cortico-cortical connectivity, we recorded in vitro M1, during an incision to sever lateral connections between M1 and S1 cortices. We demonstrate that frequency distribution of MEG signals appear have closer statistically similarity with signals from integrated rather than independent LIII/LV laminae. GABAergic modulation in both modalities elicited comparable changes in the power of the beta band. Finally, cortico-cortical connectivity in sensorimotor cortex (SMC) appears to directly influence the power of the mu rhythm in LIII. These findings suggest that the MEG signal is an amalgam of outputs from LIII and LV, that multiple frequencies can arise from the same cortical area and that in vitro and MEG M1 oscillations are driven by comparable mechanisms. Finally, cortico-cortical connectivity is reflected in the power of the SMC mu rhythm.
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使用药物脑磁图确定人类皮质中 GABA 能调节的神经网络药效学。
影响因子：
4.8
作者：
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通讯作者：
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影响因子：
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影响因子：
2.5
作者：
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通讯作者：
Ilmoniemi, RJ
影响因子：
2.5
作者：
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