Nutrient levels in amniotic fluid from women with normal and neural tube defect pregnancies.
Nutrient levels in amniotic fluid from women with normal and neural tube defect pregnancies.
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正常和神经管缺陷妊娠妇女羊水中的营养水平。
DOI：
10.1159/000243747
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Finley,WH
中科院分区：
文献类型：
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作者：
Weekes,EW;Tamura,T;Davis,RO;Birch,R;Vaughn,WH;Franklin,JC;Barganier,C;Cosper,P;Finley,SC;Finley,WH
我们分析了221名分娩明显健康婴儿的妇女和8名神经管缺陷（NTD）孕妇在正常、无并发症妊娠的第二个三个月期间获得的羊水营养水平。叶酸通过微生物测定法测定，维生素B12通过放射结合法测定，锌、铜和铁通过原子吸收分光光度法测定。我们发现，正常妊娠的平均羊水营养水平为叶酸24.7nmol/l，维生素B12 600 pmol/l，锌、铜和铁分别为1.7、1.9和9.0 μmol/l。NTD孕妇羊水叶酸、锌、铜、铁水平与正常孕妇相似，而维生素B12水平明显低于正常孕妇。
We analyzed nutrient levels in amniotic fluid obtained during the second trimester of normal, uncomplicated pregnancies from 221 women who delivered apparently healthy infants and from 8 with neural tube defect (NTD) pregnancies. Folate was measured by microbiological assay, vitamin B12by a radiobinding method, and zinc, copper and iron by atomic absorption spectrophotometry. We found that the mean amniotic fluid nutrient levels of normal pregnancies were 24.7nmol/l for folate, 600pmol/l for vitamin B12, and 1.7, 1.9, and 9.0 μmol/l for zinc, copper and iron, respectively. Amniotic fluid folate, zinc, copper and iron levels of NTD pregnancies were similar to those found during normal pregnancy, however, vitamin B12levels were markedly lower than those of normal pregnancies.