Sexual concerns in cancer patients: a comparison of GI and breast cancer patients.
Sexual concerns in cancer patients: a comparison of GI and breast cancer patients.
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DOI：
10.1007/s00520-009-0738-8
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发表时间：
2010-09
影响因子：
3.1
通讯作者：
Abernethy, Amy P.
中科院分区：
文献类型：
--
作者：
Reese, Jennifer Barsky;Shelby, Rebecca A.;Keefe, Francis J.;Porter, Laura S.;Abernethy, Amy P.
关键词：
尽管在乳腺癌（BC）患者中已经发现了性方面的顾虑，但在胃肠道（GI）癌症患者中，这些顾虑仍未得到充分的研究和治疗。目的是：(1)比较胃肠道癌患者与乳腺癌患者的性问题；(2)检查胃肠道和乳腺癌患者的性担忧是否随时间稳定；(3)评估胃肠道和乳腺癌中的性问题是否与生活质量、症状严重程度和疾病干扰显著相关，以及这些关联是否随时间而改变。数据收集于GI和乳腺癌患者在6个月内的4次门诊就诊期间。测量包括性问题（性享受、性兴趣或性表现减少）、生活质量（FACT-G）、症状严重程度、疾病干扰（MD安德森症状量表）和疾病相关的困扰（NCCN困扰量表）。进行了线性混合模型分析。性担忧在这两个样本中都很常见，57%的胃肠道癌患者和53%的乳腺癌患者报告至少有轻微的性担忧。随着时间的推移，性担忧是稳定的，并且与多个领域（例如，生活质量、症状严重程度、疾病干扰和疾病相关的痛苦）的较低功能水平显著相关，与诊断后的时间长短无关。癌症类型（GI/乳腺癌）不是这种关系的调节因子。对于胃肠道和乳腺癌患者，自我报告的性担忧是常见的、稳定的，并且与生活质量、症状严重程度、疾病干扰和疾病相关的痛苦显著相关。讨论了未来研究的局限性和意义。
Although sexual concerns have been examined in breast cancer (BC), these concerns remain understudied and undertreated for patients with gastrointestinal (GI) cancer. Objectives were to: (1) assess sexual concerns in GI cancer patients compared with breast cancer patients; (2) examine whether sexual concerns are stable over time in GI and breast cancer patients; and (3) evaluate whether sexual concerns in GI and breast cancer are significantly associated with quality of life, symptom severity, and disease interference, and whether these associations change over time. Data were collected from GI and breast cancer patients during four outpatient clinic visits over 6 months. Measures included sexual concerns (reduced sexual enjoyment, interest, or performance), quality of life (FACT-G), symptom severity, disease interference (MD Anderson Symptom Inventory), and disease-related distress (NCCN Distress Scale). Linear mixed model analyses were conducted. Sexual concerns were common in both samples, with 57% of GI cancer patients and 53% of breast cancer patients reporting at least mild sexual concerns. Sexual concerns were stable over time and were significantly associated with lower levels of functioning in multiple domains (e.g., quality of life, symptom severity, disease interference, and disease-related distress), irrespective of length of time since diagnosis. Cancer type (GI/breast cancer) was not a moderator of this relationship. Self-reported sexual concerns were common, stable, and related significantly to quality of life, symptom severity, disease interference, and disease-related distress for both GI and breast cancer patients. Limitations and implications for future research are discussed.
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