Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease
Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2004.09.004
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发表时间：
2005-07-01
影响因子：
4.2
通讯作者：
Arai, H
中科院分区：
文献类型：
--
作者：
Shibata, N;Ohnuma, T;Arai, H
近年来的研究表明，基质金属蛋白酶（MMPs）可能在阿尔茨海默病（AD）的病理生理过程中发挥重要作用。据报道，MMP-9和MMP-3降解淀粉样蛋白P，并具有与其他常见疾病相关的几种功能多态性。在AD患者和正常对照组中检测了MMP-9和MMP-3的四种常见多态性。MMP-9的常见多态性rs3918248、rs 2664538、rs 2250889和rs 2274756与AD风险无关。我们在日本样本中观察到rs 2664538和rs 2250889之间存在强烈的连锁年龄不平衡（LD）。MMP-3基因启动子5A/6A插入多态性rs3025079、rs 520540和rs679620也不影响AD的风险。5A/6A多态性与rs679620的LD相对较强。这些结果表明，MMP-9和MMP-3的常见多态性与AD无关。(c)2004年爱思唯尔公司All rights reserved.
Recent studies suggested that matrix metalloproteinases (MMPs) might play an important role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and MMP-3 are reported to degrade amyloid P and have several functional polymorphisms associated with other common diseases. Four common polymorphisms in each of MMP-9 and MMP-3 were examined in AD cases and normal control individuals. Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD. We observed strong link-age disequilibrium (LD) between rs2664538 and rs2250889 in our Japanese samples. The polymorphisms of MMP-3; 5A/6A insertion polymorphism in the promoter, rs3025079, rs520540 and rs679620 also did not influence risk for AD. LD of the 5A/6A polymorphism with rs679620 was relatively strong. These results suggest that the common polymorphisms of MMP-9 and MMP-3 investigated here are not associated with AD. (c) 2004 Elsevier Inc. All rights reserved.