Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization
Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization
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后肢体感信息影响躯干感觉和运动皮层以支持躯干稳定
DOI：
10.1093/cercor/bhab150
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Moxon, Karen A
中科院分区：
文献类型：
--
作者：
Nandakumar, Bharadwaj;Blumenthal, Gary H;Pauzin, Francois Philippe;Moxon, Karen A
躯干系统中的感觉运动整合尽管对神经损伤后的功能恢复很重要，但了解甚少。为了解决这一问题，在大鼠中进行了一系列定位研究。首先，从胸背根神经节记录的细胞的感受野（RF）进行了鉴定。第二，从躯干初级感觉皮层（S1）记录的细胞的RF用于评估躯干S1的范围和内部组织。最后，躯干运动皮层（M1）映射使用皮质内微刺激，以评估共激活的躯干肌肉与后肢和前肢肌肉，并与S1的整合。从躯干S1到躯干M1的投射在解剖学上没有组织，与后肢S1/M1和躯干M1之间的广泛整合相比，躯干S1和M1之间的感觉运动整合相对较弱。评估的反应潜伏期和解剖跟踪表明，躯干M1是丰富的指导后肢体感信息，主要来自丘脑。最后，从清醒的动物在意想不到的姿势扰动的神经记录支持后肢S1和躯干M1之间的感觉运动的整合，提供洞察躯干系统的姿势控制，是有用的研究损伤后恢复的作用。
Sensorimotor integration in the trunk system is poorly understood despite its importance for functional recovery after neurological injury. To address this, a series of mapping studies were performed in the rat. First, the receptive fields (RFs) of cells recorded from thoracic dorsal root ganglia were identified. Second, the RFs of cells recorded from trunk primary sensory cortex (S1) were used to assess the extent and internal organization of trunk S1. Finally, the trunk motor cortex (M1) was mapped using intracortical microstimulation to assess coactivation of trunk muscles with hindlimb and forelimb muscles, and integration with S1. Projections from trunk S1 to trunk M1 were not anatomically organized, with relatively weak sensorimotor integration between trunk S1 and M1 compared to extensive integration between hindlimb S1/M1 and trunk M1. Assessment of response latency and anatomical tracing suggest that trunk M1 is abundantly guided by hindlimb somatosensory information that is derived primarily from the thalamus. Finally, neural recordings from awake animals during unexpected postural perturbations support sensorimotor integration between hindlimb S1 and trunk M1, providing insight into the role of the trunk system in postural control that is useful when studying recovery after injury.