UNDERSTANDING ORGANISATION OF RETINAL RECEPTOR SYNAPSES
UNDERSTANDING ORGANISATION OF RETINAL RECEPTOR SYNAPSES
复制标题
DOI：
10.1016/0006-8993(71)90591-9
复制
发表时间：
1971-01-01
期刊：
影响因子：
2.9
通讯作者：
PEASE, HL
中科院分区：
文献类型：
--
作者：
GRAY, EG;PEASE, HL
通过适当的技术，视网膜受体（一级）突触显示包含普通突触囊泡，复杂（包被）囊泡和壳片段。复杂的囊泡似乎完全是从突触前膜的区域中萌芽出来的，该区域排列在突触带两侧的小袋上。没有复杂的囊泡被包括在突触囊泡中，这些突触囊泡形成了一个环。最外排（或两排）带状囊泡的囊泡与突触前膜紧密接触，而与该接触区相对的部分突触后（水平细胞）膜（可能是释放递质的地方）沿其细胞质表面有一条“突触后增厚”的矩形带。将这些突触的形态与大脑中的突触形态进行比较。这两种类型都有简单的突触囊泡和复杂的囊泡和壳碎片，这表明在这两种情况下，突触囊泡都是由复杂的囊泡产生的。后者，在脑突触中，是由突触前袋的外侧壁形成的，而在视网膜突触中，它们的形成仅限于外侧袋。空壳和壳碎片（通过电子立体观察证实）被限制在与小袋接壤的突触前细胞质中。在脑突触中，密集的突出物可能在引导突触囊泡经过一个区域到达突触前膜方面起作用；在视网膜突触中，带状带可能起作用，囊泡被引导到一条狭窄的突触前膜上。
With the appropriate techniques the retinal receptor (first order) synapse is shown to contain plain synaptic vesicles, complex (coated) vesicles and shell fragments. The complex vesicles appear to be budded off exclusively from that zone of the presynaptic membrane that lines the pouches that lie one on each side of the synaptic ribbon. No complex vesicles are ever included with the synaptic vesicles that form a halo round the ribbon. The vesicles of the outermost row (or two rows) of ribbon vesicles lie in close contact with the presynaptic membrane and that part of the postsynaptic (horizontal cell) membrane opposite this contact zone (presumably where the transmitter is released) has a rectangular strip of ‘postsynaptic thickening’ along its cytoplasmic surface. A comparison is made between the morphology of these synapses and those that occur in the brain. Both types have plain synaptic vesicles and complex vesicles and shell fragments, suggesting that in both cases the synaptic vesicles have arisen from the complex vesicles. The latter, in the brain synapse, have formed from the lateral walls of the presynaptic bags whereas in the retinal synapses their formation is restricted to the lateral pouches. Empty shells and shell fragments (confirmed by electron stereoscopy) are restricted to the presynaptic cytoplasm bordering the pouches. In the brain synapse the dense projections may play a part in guiding the synaptic vesicles to the presynaptic membrane over an area: in the retinal synapse the ribbon may play this role and the vesicles are guided to a narrow strip of presynaptic membrane.