Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways
Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways
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DOI：
10.1016/j.bbamcr.2011.07.011
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发表时间：
2012-01-01
影响因子：
5.1
通讯作者：
Ossareh-Nazari, Batool
中科院分区：
文献类型：
--
作者：
Dargemont, Catherine;Ossareh-Nazari, Batool
aaa - atp酶Cdc48/p97通过其与泛素化蛋白的相互作用和控制命运的能力控制大量的细胞功能，包括蛋白质降解，细胞分裂，膜融合。最近，Cdc48/p97似乎也参与自噬，这是一种分解代谢细胞反应，长期以来被认为与泛素/蛋白酶体系统完全不同。特别是，泛素或泛素样蛋白以及泛素结合蛋白（如Cdc48/p97及其辅助因子）的结合可以通过两种分解代谢途径靶向降解。本文将重点介绍Cdc48/p97在自噬体生物发生和选择性自噬中的作用。本文是《AAA atp酶：结构和功能》特刊的一部分。(C) 2011 Elsevier B.V.版权所有
The AAA-ATPase Cdc48/p97 controls a large array of cellular functions including protein degradation, cell division, membrane fusion through its ability to interact with and control the fate of ubiquitylated proteins. More recently, Cdc48/p97 also appeared to be involved in autophagy, a catabolic cell response that has long been viewed as completely distinct from the Ubiquitine/Proteasome System. In particular, conjugation by ubiquitin or ubiquitin-like proteins as well as ubiquitin binding proteins such as Cdc48/p97 and its cofactors can target degradation by both catabolic pathways. This review will focus on the recently described functions of Cdc48/p97 in autophagosome biogenesis as well as selective autophagy. This article is part of a Special Issue entitled: AAA ATPases: structure and function. (C) 2011 Elsevier B.V. All rights reserved.