Gender and age-related differences in Burkitt lymphoma - epidemiological and clinical data from The Netherlands
Gender and age-related differences in Burkitt lymphoma - epidemiological and clinical data from The Netherlands
复制标题
DOI：
10.1016/j.ejca.2004.09.004
复制
发表时间：
2004-12-01
影响因子：
8.4
通讯作者：
Kluin-Nelemans, JC
中科院分区：
文献类型：
--
作者：
Boerma, EG;van Imhoff, GW;Kluin-Nelemans, JC
虽然伯基特淋巴瘤（BL）在世界卫生组织（WHO）分类中被列为一个实体，但我们想知道BL是否不应被视为儿童与成人不同的疾病。从1994年至1998年获得荷兰癌症登记处（NCR）的数据（n = 203）。比较了两种治疗方案的详细临床数据：一种用于65岁以下的成人（n = 27），另一种用于儿童（n = 80）。对两项临床研究的所有切片进行集中审查，包括MYC/8 q24的免疫表型分析和必要时的断点分析。仅接受明确诊断BL（经典和非典型BL）的病例。BL患者的年龄分布呈双峰分布，在儿科年龄达到峰值，在约60岁后稳定增加。大多数患者为男性（89%为儿童，78%为成人），只有男性患者表现出这种双峰性。儿童更常患有淋巴结疾病（81%对59%），而成人更常患有淋巴结疾病（89%对53%）。基于流行病学和临床表现，BL是一种疾病的概念应该重新挑战。(C)2004爱思唯尔有限公司保留所有权利。
Although Burkitt's lymphoma (BL) is classified as one entity in the World Health Organisation (WHO) classification, we wondered whether BL should not be considered as a different disease in children compared with adults. Netherlands Cancer Registry (NCR) data were obtained from 1994 to 1998 (n = 203). Detailed clinical data from two treatment protocols were compared: one for adults up to the age of 65 years (n = 27) and one for children (n = 80). All slides of the two clinical studies were centrally reviewed which included immunophenotyping and when necessary breakpoint analysis of MYC/8q24. Only cases with an unambiguous diagnosis of BL (classical and atypical BL) were accepted. The age distribution of BL-patients showed a bimodal distribution with a peak at the paediatric age and a steady increase after approximately 60 years of age. Most of the patients were males (89% for children and 78% for adults) and only male patients showed this bimodality. Children more often had extranodal disease (81% vs. 59%), whereas adults more often had nodal disease (89% vs. 53%). Based on epidemiology and clinical presentation, the concept that BL is one disease should be re-challenged. (C) 2004 Elsevier Ltd. All rights reserved.