Studying higher cerebral functions by transcranial magnetic stimulation.
Studying higher cerebral functions by transcranial magnetic stimulation.
复制标题
DOI：
--
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Y. Terao;Y. Ugawa
中科院分区：
文献类型：
--
作者：
Y. Terao;Y. Ugawa
经颅磁刺激可通过虚拟损伤模式研究高级脑功能。这种方法的主要优点是，它可以用来在研究人员想要的任何地方产生损伤，而不会混淆皮层重组，并且它有助于在大脑活动和行为之间建立因果链。随着对皮层功能阻滞机制的阐明，该技术将为研究高级脑功能开辟新的可能性。与在受试者执行特定任务时提供TMS的在线方法相反，离线方法使用重复的TMS来实现持久的效果，即使在刺激停止后。离线方法的应用将从TMS改善认知功能扩展到神经和精神病患者的治疗。
TMS can be used to study higher cerebral functions by the virtual lesion paradigm. The major advantages of this method are that it could be used to produce a lesion anywhere the researcher wants without confusing cortical reorganization, and that it helps to establish a chain of cause and effect between the activity of the brain and behavior. With elucidation of the mechanism underlying the cortical function blocking, this technique will open up new possibilities for studying higher cerebral functions. In contrast to the online method in which TMS is delivered while subjects perform a certain task, the off-line method uses repetitive TMS to achieve lasting effects even after stimulation has ceased. The application of the offline method will extend from improving cognitive functions by TMS to the treatment of neurological and psychiatric patients.