Acute in vivo evaluation of an implantable continuous flow biventricular assist system.
Acute in vivo evaluation of an implantable continuous flow biventricular assist system.
复制标题
植入式连续流双心室辅助系统的急性体内评估。
DOI：
10.1097/mat.0b013e31815b2d1e
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Fukamachi,Ki
中科院分区：
文献类型：
--
作者：
Saeed,Diyar;Ootaki,Yoshio;Ootaki,Chiyo;Akiyama,Masatoshi;Horai,Tetsuya;Catanese,Jacquelyn;Fumoto,Hideyuki;Dessoffy,Raymond;Massiello,AlexL;Horvath,DavidJ;Zhou,Qun;Chen,Ji-Feng;Benefit,Stephen;Golding,LeonardAR;Fukamachi,Ki
植入式双心室辅助装置为挽救不可逆左右心室衰竭患者的生命提供了巨大的机会。本研究的目的是评估联合植入 CorAide™ 左心室辅助装置 (LVAD) 和 DexAide 右心室辅助装置 (RVAD) 的血流动力学和生理性能。在模拟两只小牛的七种不同的生理条件后，评估了急性血流动力学反应。通过固定一个单独泵的速度并增加另一个泵的速度来进行评估。在所有条件下，增加 LVAD 或 RVAD 速度都会导致泵流量增加。独立改变 DexAide 和 CorAide 泵速的主要病理生理效应是，左心房压力对 RVAD 速度增加到 2,400 rpm 以上非常敏感，而右心房压力对 LVAD 速度增加的敏感性要低得多。在增加 LVAD 速度的同时，观察到主动脉压和 RVAD 流量增加，特别是在低收缩力、心室颤动、高肺动脉压和低循环血容量条件下。总之，应通过避免 RVAD 过载来维持适当的 RVAD-LVAD 平衡。其他研究将进一步研究这些泵在慢性动物模型中的性能。
An implantable biventricular assist device offers a considerable opportunity to save the lives of patients with combined irreversible right and left ventricular failure. The purpose of this study was to evaluate the hemodynamic and physiologic performance of the combined implantation of the CorAide™ left ventricular assist device (LVAD) and the DexAide right ventricular assist device (RVAD). Acute hemodynamic responses were evaluated after simulating seven different physiological conditions in two calves. Evaluation was performed by fixing the speed of one individual pump and increasing the speed of the other. Under all conditions, increased LVAD or RVAD speed resulted in increased pump flow. The predominant pathophysiologic effect of independently varying DexAide and CorAide pump speeds was that the left atrial pressure was very sensitive to increasing RVAD speed above 2,400 rpm, whereas the right atrial pressure demonstrated much less sensitivity to increasing LVAD speed. An increase in aortic pressure and RVAD flow was observed while increasing LVAD speed, especially under low contractility, ventricular fibrillation, high pulmonary artery pressure, and low circulatory blood volume conditions. In conclusion, a proper RVAD-LVAD balance should be maintained by avoiding RVAD overdrive. Additional studies will further investigate the performance of these pumps in chronic animal models.